Synthesis and antimicrobial evaluation of novel pyrimidine-5-carboxamide scaffold

被引：0
|
作者：
Ghodasara, Hardik B. [1 ]
Patel, Bharat G. [1 ]
Shah, Viresh H. [1 ]
机构：
[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 04期
关键词：
Pyrimidine; carboxamide; antibacterial; antiftmgal; biological assay; DIHYDROPYRIMIDINES; POTENT;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis and biological evaluation of pyrimidine-5-carboxamide derivatives containing 2,4-diamino substituted derivatives have been described. Biginelli typed three component reactions between an aldehyde, malononitrile and a guanidine constituent gives a rapid facile pyrimidine ring. The constitution of the products has been delineated by elemental analysis and spectral analysis: The products have been assayed for their in vitro biological assay antibacterial activity against S. pyogens MTCC-442, S. aurues MTCC-96, E. coli MTCC-443, B. subtillitis MTCC-441 bacterial strain and antifungal activity against Aspergillus, niger MTCC-282 and Candida albicans MTCC-227 at different concentrations and compared with Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin and Griseofulvin as standard drug results of which are presented.
引用
收藏
页码：419 / 425
页数：7
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