Synthesis and antimicrobial evaluation of novel pyrimidine-5-carboxamide scaffold

Synthesis and biological evaluation of pyrimidine-5-carboxamide derivatives containing 2,4-diamino substituted derivatives have been described. Biginelli typed three component reactions between an aldehyde, malononitrile and a guanidine constituent gives a rapid facile pyrimidine ring. The constitution of the products has been delineated by elemental analysis and spectral analysis: The products have been assayed for their in vitro biological assay antibacterial activity against S. pyogens MTCC-442, S. aurues MTCC-96, E. coli MTCC-443, B. subtillitis MTCC-441 bacterial strain and antifungal activity against Aspergillus, niger MTCC-282 and Candida albicans MTCC-227 at different concentrations and compared with Ampicillin, Chloramphenicol, Ciprofloxacin, Norfloxacin and Griseofulvin as standard drug results of which are presented.