Design of artificial genetic regulatory networks with multiple delayed adaptive responses

被引:4
|
作者
Kaluza, Pablo [1 ,2 ,3 ]
Inoue, Masayo [4 ,5 ]
机构
[1] Natl Univ Cuyo, Natl Sci & Tech Res Council, Padre Contreras 1300, RA-5500 Mendoza, Argentina
[2] Natl Univ Cuyo, Fac Exact & Nat Sci, Padre Contreras 1300, RA-5500 Mendoza, Argentina
[3] Max Planck Gesell, Fritz Haber Inst, Phys Chem Abt, Faradayweg 4-6, D-14195 Berlin, Germany
[4] Natl Inst Adv Ind Sci & Technol, Mol Profiling Res Ctr Drug Discovery, 2-4-7 Aomi, Tokyo 1350064, Japan
[5] Osaka Univ, Cybermedia Ctr, Toyonaka, Osaka 5600043, Japan
来源
EUROPEAN PHYSICAL JOURNAL B | 2016年 / 89卷 / 06期
关键词
ENVIRONMENTAL-CHANGES; ADAPTATION; EXPRESSION; ROBUST;
D O I
10.1140/epjb/e2016-70172-9
中图分类号
O469 [凝聚态物理学];
学科分类号
070205 ;
摘要
Genetic regulatory networks with adaptive responses are widely studied in biology. Usually, models consisting only of a few nodes have been considered. They present one input receptor for activation and one output node where the adaptive response is computed. In this work, we design genetic regulatory networks with many receptors and many output nodes able to produce delayed adaptive responses. This design is performed by using an evolutionary algorithm of mutations and selections that minimizes an error function defined by the adaptive response in signal shapes. We present several examples of network constructions with a predefined required set of adaptive delayed responses. We show that an output node can have different kinds of responses as a function of the activated receptor. Additionally, complex network structures are presented since processing nodes can be involved in several input-output pathways.
引用
收藏
页数:11
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