Current advances in HIV vaccine preclinical studies using Macaque models

被引：14

作者：

Liang, Binhua ^{[1
,2
]}

Li, Hongzhao ^{[3
]}

Li, Lin ^{[1
]}

Omange, Robert Were ^{[3
]}

Hai, Yan ^{[3
]}

Luo, Ma ^{[1
,3
]}

机构：

[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada

[2] Univ Manitoba, Biochem & Med Genet, Winnipeg, MB, Canada

[3] Univ Manitoba, Med Microbiol & Infect Dis, Winnipeg, MB, Canada

来源：

VACCINE | 2019年 / 37卷 / 26期

关键词：

Vaccine; Macaque; Simian immunodeficiency virus; Repeated-low-dose challenge; Vaccine efficacy; SIMIAN IMMUNODEFICIENCY VIRUS; CD4(+) T-CELLS; RHESUS MACAQUES; CYNOMOLGUS MACAQUES; SIV INFECTION; REVERSE-TRANSCRIPTASE; RIBONUCLEASE-ACTIVITY; GAG/POL/NEF VACCINE; SIVMAC239; INFECTION; PROTECTIVE EFFICACY;

D O I：

10.1016/j.vaccine.2019.04.094

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The macaque simian or simian/human immunodeficiency virus (SIV/SHIV) challenge model has been widely used to inform and guide human vaccine trials. Substantial advances have been made recently in the application of repeated-low-dose challenge (RLD) approach to assess SIV/SHIV vaccine efficacies (VE). Some candidate HIV vaccines have shown protective effects in preclinical studies using the macaque SIV/SHIV model but the model's true predictive value for screening potential HIV vaccine candidates needs to be evaluated further. Here, we review key parameters used in the RLD approach and discuss their relevance for evaluating VE to improve preclinical studies of candidate HIV vaccines. Crown Copyright (C) 2019 Published by Elsevier Ltd. All rights reserved.

引用

页码：3388 / 3399

页数：12

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