A STRETCHABLE CELL CULTURE PLATFORM WITH EMBEDDED ELECTRODE ARRAY

被引：5
|
作者：
Wei, P. [1 ,2 ]
Taylor, R. [4 ]
Ding, Z. [2 ,3 ]
Higgs, G. [4 ]
Norman, J. J. [4 ,5 ]
Pruitt, B. L. [4 ]
Ziaie, B. [1 ,2 ]
机构：
[1] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA
[2] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA
[3] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA
[4] Stanford Univ, Dept Mech Engn, Stanford, CA USA
[5] Stanford Med Sch, Dept Pediat Cardiol, Stanford, CA USA
来源：
IEEE 22ND INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2009) | 2009年
关键词：
D O I：
10.1109/MEMSYS.2009.4805405
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
In this paper, we present a stretchable electrode array for studying cell behavior subjected to mechanical strain. The electrode array consists of four gold nail-head pins (250 mu m tip diameter and 1.75mm spacing) inserted into a polydimethylsiloxane (PDMS) platform (25.4x25.4mm(2)). Fusible indium alloy (liquid at room temperature) filled microchannels are used to connect the electrodes to the outside, thus providing the required stretchability. The electrode platform is biocompatible and can withstand strains of up to 40%. We tested these electrodes by repeatedly (100 times) subjecting them to 3500 strain and did not notice any failure. We also successfully cultured mice cardiomyocytes onto the platform and performed electrical pacing.
引用
收藏
页码：407 / 410
页数：4
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