Carbonylative C-C Bond Activation of Aminocyclopropanes Using a Temporary Directing Group Strategy

被引：24
|
作者：
Wang, Gang-Wei [1 ]
Sokolova, Olga O. [1 ]
Young, Tom A. [2 ]
Christodoulou, Ektor M. S. [1 ]
Butts, Craig P. [1 ]
Bower, John F. [1 ,3 ]
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[2] Univ Oxford, Phys & Theoret Lab, Oxford OX1 3QZ, England
[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 45期
基金：
欧洲研究理事会; 英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/jacs.0c08973
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Temporary directing groups (TDGs) underpin a range of C-C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C-C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C-C bond activations.
引用
收藏
页码：19006 / 19011
页数：6
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