Carbonylative C-C Bond Activation of Aminocyclopropanes Using a Temporary Directing Group Strategy

被引：24

作者：

Wang, Gang-Wei ^{[1
]}

Sokolova, Olga O. ^{[1
]}

Young, Tom A. ^{[2
]}

Christodoulou, Ektor M. S. ^{[1
]}

Butts, Craig P. ^{[1
]}

Bower, John F. ^{[1
,3
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ Oxford, Phys & Theoret Lab, Oxford OX1 3QZ, England

[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 45期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/jacs.0c08973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Temporary directing groups (TDGs) underpin a range of C-C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C-C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C-C bond activations.

引用

页码：19006 / 19011

页数：6

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