Involvement of the Long-Chain Fatty Acid Receptor GPR40 in Depression-Related Behavior

被引：24
|
作者：
Nishinaka, Takashi [1 ]
Yamashita, Takuya [2 ]
Nakamoto, Kazuo [1 ]
Kasuya, Fumiyo [2 ]
Tokuyama, Shogo [1 ]
机构：
[1] Kobe Gakuin Univ, Sch Pharmaceut Sci, Dept Clin Pharm, Chuo Ku, Kobe, Hyogo 6508586, Japan
[2] Kobe Gakuin Univ, Sch Pharmaceut Sci, Biochem Toxicol Lab, Chuo Ku, Kobe, Hyogo 6508586, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2014年 / 125卷 / 01期
关键词：
G protein-coupled receptor 40; depression; free fatty acid; DOCOSAHEXAENOIC ACID; NEUROTROPHIC FACTOR; BRAIN;
D O I：
10.1254/jphs.14001SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The functional role of brain G protein-coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.
引用
收藏
页码：112 / 115
页数：4
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