Involvement of the Long-Chain Fatty Acid Receptor GPR40 in Depression-Related Behavior

被引：24

作者：

Nishinaka, Takashi ^{[1
]}

Yamashita, Takuya ^{[2
]}

Nakamoto, Kazuo ^{[1
]}

Kasuya, Fumiyo ^{[2
]}

Tokuyama, Shogo ^{[1
]}

机构：

[1] Kobe Gakuin Univ, Sch Pharmaceut Sci, Dept Clin Pharm, Chuo Ku, Kobe, Hyogo 6508586, Japan

[2] Kobe Gakuin Univ, Sch Pharmaceut Sci, Biochem Toxicol Lab, Chuo Ku, Kobe, Hyogo 6508586, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2014年 / 125卷 / 01期

关键词：

G protein-coupled receptor 40; depression; free fatty acid; DOCOSAHEXAENOIC ACID; NEUROTROPHIC FACTOR; BRAIN;

D O I：

10.1254/jphs.14001SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The functional role of brain G protein-coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.

引用

页码：112 / 115

页数：4

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