One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases

被引：11

作者：

Van Voorhis, Wesley C. ^{[1
]}

Hulverson, Matthew A. ^{[1
]}

Choi, Ryan ^{[1
]}

Huang, Wenlin ^{[2
]}

Arnold, Samuel L. M. ^{[1
]}

Schaefer, Deborah A. ^{[3
]}

Betzer, Dana P. ^{[5
]}

Vidadala, Rama S. R. ^{[4
]}

Lee, Sangun ^{[6
]}

Whitman, Grant R. ^{[1
]}

Barrett, Lynn K. ^{[1
]}

Maly, Dustin J. ^{[4
]}

Riggs, Michael W. ^{[3
]}

Fan, Erkang ^{[2
]}

Kennedy, Thomas J. ^{[5
]}

Tzipori, Saul ^{[6
]}

Doggett, J. Stone ^{[7
]}

Winzer, Pablo ^{[8
]}

Anghel, Nicoleta ^{[8
]}

Imhof, Dennis ^{[2
]}

Muller, Joachim ^{[8
]}

Hemphill, Andrew ^{[8
]}

Ferre, Ignacio ^{[9
]}

Sanchez-Sanchez, Roberto ^{[9
]}

Ortega-Mora, Luis Miguel ^{[9
]}

Ojo, Kayode K. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Allergy & Infect Dis, Ctr Emerging & Re Emerging Infect Dis CERID, Seattle, WA 98109 USA

[2] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[3] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA

[4] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[5] Eleven Bravo LLC, Westport, WI 53597 USA

[6] Tufts Univ, Cummings Sch Vet Med, Dept Infect Dis & Global Hlth, North Grafton, MA 01536 USA

[7] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[8] Univ Bern, Vetsuisse Fac, Inst Parasitol, Dept Infect Dis & Pathobiol, CH-3012 Bern, Switzerland

[9] Univ Complutense Madrid, Fac Vet Sci, Anim Hlth Dept, Saluvet, Ciudad Univ S-N, Madrid 28040, Spain

来源：

VETERINARY PARASITOLOGY | 2021年 / 289卷

基金：

美国食品与农业研究所; 比尔及梅琳达.盖茨基金会; 瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

Antiparastics; Apicomplexa; Kinase inhibitors; BUMPED-KINASE INHIBITORS; TOXOPLASMA-GONDII; SELECTIVE INHIBITORS; NEOSPORA-CANINUM; PROTEIN-KINASES; C; PARVUM; IN-VITRO; POTENT; CHILDREN; EFFICACY;

D O I：

10.1016/j.vetpar.2020.109336

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neospomsis. We have demon-strated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.

引用

页数：7

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