Reductionism and proxy failure: From neuroscience to target-based drug discovery

被引：0
|
作者：
Sadri, Arash [1 ,2 ]
Paknezhad, Sepideh [3 ]
机构：
[1] Lyceum Sci Char, Tehran, Iran
[2] Univ Tehran Med Sci, Students Sci Res Ctr, Interdisciplinary Neurosci Res Program INRP, Tehran, Iran
[3] Islamic Azad Univ, Dept Psychol, Sari Branch, Sari, Iran
来源：
BEHAVIORAL AND BRAIN SCIENCES | 2024年 / 47卷
关键词：
D O I：
10.1017/S0140525X23002893
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery.
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