IL7RA polymorphisms and chronic inflammatory arthropathies

被引：35
|
作者：
O'Doherty, C.
Alloza, I. [1 ,2 ]
Rooney, M. [3 ]
Vandenbroeck, K. [1 ,2 ]
机构：
[1] Ikerbasque, Neurogenom, Leioa, Spain
[2] Univ Basque Country, EHU, Leioa, Spain
[3] Queens Univ Belfast, Dept Rheumatol, Musgrave Pk Hosp, Belfast, Antrim, North Ireland
来源：
TISSUE ANTIGENS | 2009年 / 74卷 / 05期
关键词：
interleukin-7 receptor alpha subunit; juvenile idiopathic arthritis; rheumatoid arthritis; single nucleotide polymorphism; MULTIPLE-SCLEROSIS; INTERLEUKIN-7; RECEPTOR; ARTHRITIS; RISK;
D O I：
10.1111/j.1399-0039.2009.01342.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
引用
收藏
页码：429 / 431
页数：3
相关论文
共 50 条
  • [31] The IL7RA rs6897932 polymorphism is associated with progression of liver fibrosis in patients with chronic hepatitis C: Repeated measurements design
    Angeles Jimenez-Sousa, Maria
    Zaida Gomez-Moreno, Ana
    Pineda-Tenor, Daniel
    Maria Medrano, Luz
    Jose Sanchez-Ruano, Juan
    Fernandez-Rodriguez, Amanda
    Artaza-Varasa, Tomas
    Saura-Montalban, Jose
    Vazquez-Moron, Sonia
    Ryan, Pablo
    Resino, Salvador
    PLOS ONE, 2018, 13 (05):
  • [32] IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?
    Christian Lundtoft
    Julia Seyfarth
    Marc Jacobsen
    Genes & Immunity, 2020, 21 : 83 - 90
  • [33] IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?
    Lundtoft, Christian
    Seyfarth, Julia
    Jacobsen, Marc
    GENES AND IMMUNITY, 2020, 21 (02) : 83 - 90
  • [34] T-CELL- AND ANTIBODY-MEDIATED AUTOIMMUNE MANIFESTATIONS IN SCID DUE TO IL7RA MUTATIONS
    Zago, C. A.
    Jacob, C. M. A.
    Diniz, E. M. D. A.
    Zerbini, C.
    Dorna, M.
    Fernandes, J.
    Rocha, V.
    Oliveira, J. B.
    Carneiro-Sampaio, M.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2012, 32 : 68 - 69
  • [35] Reduced expression of the IL7Ra signaling pathway contributes to T-cell pathogenesis in NMO.
    Brill, L.
    Lavon, I.
    Dembinsky, A. Vaknin
    EUROPEAN JOURNAL OF NEUROLOGY, 2018, 25 : 323 - 323
  • [36] Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation
    Lev, Atar
    Simon, Amos J.
    Barel, Ortal
    Eyal, Eran
    Glick-Saar, Efrat
    Nayshool, Omri
    Birk, Ohad
    Stauber, Tali
    Hochberg, Amit
    Broides, Arnon
    Almashanu, Shlomo
    Hendel, Ayal
    Lee, Yu Nee
    Somech, Raz
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [37] Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity
    Campos, Livia Weijenborg
    Zenatti, Priscila Pini
    Pissinato, Leonardo Granato
    Rodrigues, Gisele O. Libanio
    Artico, Leonardo Luis
    Guimaraes, Thais Rafael
    Archangelo, Leticia Frohlich
    Martinez, Leandro
    Brooks, Andrew J.
    Yunes, Jose Andres
    BLOOD, 2019, 133 (11) : 1259 - 1263
  • [38] Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression
    Lundtoft, Christian
    Seyfarth, Julia
    Oberstrass, Sonja
    Rosenbauer, Joachim
    Baechle, Christina
    Roden, Michael
    Holl, Reinhard W.
    Mayatepek, Ertan
    Kummer, Sebastian
    Meissner, Thomas
    Jacobsen, Marc
    JOURNAL OF AUTOIMMUNITY, 2019, 97 : 40 - 47
  • [39] IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis
    Jaeger, J.
    Schulze, C.
    Roesner, S.
    Martin, R.
    GENES AND IMMUNITY, 2013, 14 (07) : 453 - 461
  • [40] IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis
    J Jäger
    C Schulze
    S Rösner
    R Martin
    Genes & Immunity, 2013, 14 : 453 - 461
12345