IL7RA polymorphisms and chronic inflammatory arthropathies

被引：35
|
作者：
O'Doherty, C.
Alloza, I. [1 ,2 ]
Rooney, M. [3 ]
Vandenbroeck, K. [1 ,2 ]
机构：
[1] Ikerbasque, Neurogenom, Leioa, Spain
[2] Univ Basque Country, EHU, Leioa, Spain
[3] Queens Univ Belfast, Dept Rheumatol, Musgrave Pk Hosp, Belfast, Antrim, North Ireland
来源：
TISSUE ANTIGENS | 2009年 / 74卷 / 05期
关键词：
interleukin-7 receptor alpha subunit; juvenile idiopathic arthritis; rheumatoid arthritis; single nucleotide polymorphism; MULTIPLE-SCLEROSIS; INTERLEUKIN-7; RECEPTOR; ARTHRITIS; RISK;
D O I：
10.1111/j.1399-0039.2009.01342.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.
引用
收藏
页码：429 / 431
页数：3
相关论文
共 50 条
  • [21] CTLA-4 gene polymorphisms in chronic inflammatory arthropathies.
    Suppiah, V
    Heggarty, S
    O'Doherty, C
    Rooney, M
    Vandenbroeck, K
    ARTHRITIS AND RHEUMATISM, 2005, 52 (09): : S147 - S147
  • [22] THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL
    Brooks, Andrew
    Campos, Livia
    Lee, Christine
    Chhabra, Yash
    Bridgford, Jessica
    Lee, Su Min
    Zenatti, Priscila
    Pissinato, Leonardo
    Rodrigues, Gisele
    Artico, Leonardo
    Guimaraes, Thais
    Archangelo, Leticia
    Martinez, Leandro
    Slape, Christopher
    Call, Matthew
    Call, Melissa
    Yunes, Jose
    EXPERIMENTAL HEMATOLOGY, 2019, 76 : S59 - S59
  • [23] Variation in SNPs of the IL7Ra Gene is Associated with Multiple Sclerosis in the Iranian Population
    Heidari, Moones
    Behmanesh, Mehrdad
    Sahraian, Mohammad-Ali
    IMMUNOLOGICAL INVESTIGATIONS, 2011, 40 (03) : 279 - 289
  • [24] IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection
    Han, Fei
    Gulam, Muhammad Yaaseen
    Zheng, Yichao
    Zulhaimi, Nurul Syuhada
    Sia, Wan Rong
    He, Dan
    Ho, Amanda
    Hadadi, Leila
    Liu, Zhenyu
    Qin, Peiwu
    Lobie, Peter E.
    Kamarulzaman, Adeeba
    Wang, Lin-Fa
    Sandberg, Johan K.
    Lewin, Sharon R.
    Rajasuriar, Reena
    Leeansyah, Edwin
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [25] Common single nucleotide polymorphisms in the interleukin-7receptor a gene and their associations with variable expression of IL7Ra in Iranian population of multiple sclerosis patients
    Heidari, M.
    Behmanesh, M.
    Sahraian, M. A.
    MULTIPLE SCLEROSIS, 2009, 15 (09): : S65 - S65
  • [26] Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women
    Suppiah, V.
    Rooney, M.
    Vandenbroeck, K.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2006, 81 (03) : 239 - 244
  • [27] Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features
    Hoffmann, Maximilian
    Enczmann, Juergen
    Balz, Vera
    Kummer, Sebastian
    Reinauer, Christina
    Doeing, Carsten
    Foertsch, Katharina
    Welters, Alena
    Vasconcelos, Malte Kohns
    Mayatepek, Ertan
    Meissner, Thomas
    Jacobsen, Marc
    Seyfarth, Julia
    CLINICAL IMMUNOLOGY, 2022, 235
  • [28] IL7RA functional polymorphism and multiple sclerosis susceptibility: replication and meta-analysis
    Lopez-Cavanillas, M.
    de las Heras, V.
    De La Concha, E. G.
    Bartolome, M.
    Urcelay, E.
    Arroyo Gonzalez, R.
    MULTIPLE SCLEROSIS, 2009, 15 (09): : S66 - S66
  • [29] An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana
    Lundtoft, Christian
    Awuah, Anthony Afum-Adjei
    Gueler, Alptekin
    Harling, Kirstin
    Schaal, Heiner
    Mayatepek, Ertan
    Phillips, Richard O.
    Nausch, Norman
    Owusu-Dabo, Ellis
    Jacobsen, Marc
    GENES AND IMMUNITY, 2019, 20 (06) : 514 - 519
  • [30] An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana
    Christian Lundtoft
    Anthony Afum-Adjei Awuah
    Alptekin Güler
    Kirstin Harling
    Heiner Schaal
    Ertan Mayatepek
    Richard O. Phillips
    Norman Nausch
    Ellis Owusu-Dabo
    Marc Jacobsen
    Genes & Immunity, 2019, 20 : 514 - 519
12345