Hepatitis B Virus Antibody Levels 7 to 9 Years after Booster Vaccination in Alaska Native Persons

被引：12
|
作者：
Keck, James W. [1 ,2 ]
Bulkow, Lisa R. [2 ]
Raczniak, Gregory A. [1 ,2 ]
Negus, Susan E. [3 ]
Zanis, Carolyn L. [2 ]
Bruce, Michael G. [2 ]
Spradling, Philip R. [4 ]
Teshale, Eyasu H. [4 ]
McMahon, Brian J. [2 ,3 ]
机构：
[1] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA
[2] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA
[3] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA
[4] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2014年 / 21卷 / 09期
关键词：
PROTECTION; CHILDREN; IMPACT;
D O I：
10.1128/CVI.00263-14
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis B antibody persistence was assessed in individuals who had previously received a vaccine booster. We measured hepatitis B surface antigen antibody (anti-HBs) levels 7 to 9 years post-hepatitis B booster in individuals with primary vaccination at birth. While 95 (91.3%) of 104 participants had detectable anti-HBs (minimum, 0.1 mIU/ml; maximum, 1,029 mIU/ml), only 43 (41%) had protective levels of >= 10 mIU/ml. Pre- and week 4 postbooster anti-HBs levels were significant predictors of hepatitis B immunity at follow-up (P < 0.001). Almost all participants had detectable anti-HBs 7 to 9 years after the hepatitis B vaccine booster, but less than half had levels >= 10 mIU/ml.
引用
收藏
页码：1339 / 1342
页数：4
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