Hepatitis B Virus Antibody Levels 7 to 9 Years after Booster Vaccination in Alaska Native Persons

被引：12

作者：

Keck, James W. ^{[1
,2
]}

Bulkow, Lisa R. ^{[2
]}

Raczniak, Gregory A. ^{[1
,2
]}

Negus, Susan E. ^{[3
]}

Zanis, Carolyn L. ^{[2
]}

Bruce, Michael G. ^{[2
]}

Spradling, Philip R. ^{[4
]}

Teshale, Eyasu H. ^{[4
]}

McMahon, Brian J. ^{[2
,3
]}

机构：

[1] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA

[2] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA

[3] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA

[4] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2014年 / 21卷 / 09期

关键词：

PROTECTION; CHILDREN; IMPACT;

D O I：

10.1128/CVI.00263-14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis B antibody persistence was assessed in individuals who had previously received a vaccine booster. We measured hepatitis B surface antigen antibody (anti-HBs) levels 7 to 9 years post-hepatitis B booster in individuals with primary vaccination at birth. While 95 (91.3%) of 104 participants had detectable anti-HBs (minimum, 0.1 mIU/ml; maximum, 1,029 mIU/ml), only 43 (41%) had protective levels of >= 10 mIU/ml. Pre- and week 4 postbooster anti-HBs levels were significant predictors of hepatitis B immunity at follow-up (P < 0.001). Almost all participants had detectable anti-HBs 7 to 9 years after the hepatitis B vaccine booster, but less than half had levels >= 10 mIU/ml.

引用

页码：1339 / 1342

页数：4

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