New Reassortant H5N6 Highly Pathogenic Avian Influenza Viruses in Southern China, 2014

被引：19
|
作者：
Jiao, Peirong [1 ,2 ,3 ,4 ]
Cui, Jin [1 ,2 ,3 ,4 ]
Song, Yafen [1 ,2 ,3 ,4 ]
Song, Hui [1 ,2 ,3 ,4 ]
Zhao, Zhishan [1 ,5 ]
Wu, Siyu [1 ,2 ,3 ,4 ]
Qu, Nannan [1 ,2 ,3 ,4 ]
Wang, Nianchen [1 ,2 ,3 ,4 ]
Ouyang, Guowen [1 ,2 ,3 ,4 ]
Liao, Ming [1 ,2 ,3 ,4 ]
机构：
[1] Natl & Reg Joint Engn Lab Medicament Zoonosis Pre, Guangzhou, Guangdong, Peoples R China
[2] Minist Agr, Key Lab Anim Vaccine Dev, Guangzhou, Guangdong, Peoples R China
[3] Key Lab Zoonosis Prevent & Control Guangdong, Guangzhou, Guangdong, Peoples R China
[4] South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China
[5] South China Agr Univ, Coll Life Sci, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2016年 / 7卷
基金：
中国国家自然科学基金;
关键词：
H5N6; highly pathogenic avian influenza virus; ducks; evolution; pathogenicity; A-VIRUSES; HEMAGGLUTININ; POLYMERASE; DUCKS;
D O I：
10.3389/fmicb.2016.00754
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
New reassortant H5N6 highly pathogenic avian influenza viruses (AlVs) were isolated from apparently healthy domestic ducks in Southern China in 2014. Our results show that the viruses grew efficiently in eggs and replicated systemically in chickens. They were completely lethal in chicken (100% mortality), and the mean death time was 6 to 7 days post-inoculation. The viruses could transmit in chickens by naive contact. BLAST analysis revealed that their HA gene was most closely related to A/wild duck/Shangdong/628/2011 (H5N1), and their NA genes were most closely related to A/swine/Guangdong/K6/2010 (H6N6). The other genes had the highest identity with A/wild duck/Fujian/1/2011(H5N1). The results of phylogenetic analysis showed that their HA genes clustered into Glade 2.3.4.4 of the H5N1 viruses and all genes derived from H5 were Mix-like or H6-like viruses. Thus, the new H5N6 viruses were reassortmented of H5N1 and H6N6 virus. Therefore, the circulation of the new H5N6 AlVs may become a threat to poultry and human health.
引用
收藏
页数：12
相关论文
共 50 条
  • [41] Genetics, pathogenicity and transmissibility of novel reassortant H5N6 highly pathogenic avian influenza viruses first isolated from migratory birds in western China (vol 7, 6, 2018)
    Lu, S.
    Zhao, Z.
    Zhang, J.
    Wang, W.
    He, X.
    Yu, M.
    Zhang, C.
    Li, X.
    Guo, Z.
    Yang, X.
    Liu, L.
    Zhi, M.
    Fu, T.
    Lv, X.
    Ma, W.
    Liao, M.
    Chai, H.
    Liu, L.
    Qian, J.
    Ma, J.
    EMERGING MICROBES & INFECTIONS, 2019, 8 (01): : 366 - 366
  • [42] Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014-2018
    Bai, Ru
    Sikkema, Reina S.
    Li, Cong Rang
    Munnink, Bas B. Oude
    Wu, Jie
    Zou, Lirong
    Jing, Yi
    Lu, Jing
    Yuan, Runyu
    Liao, Ming
    Koopmans, Marion P. G.
    Ke, Chang-wen
    EMERGING INFECTIOUS DISEASES, 2019, 25 (10) : 1932 - 1935
  • [43] Risk Factors Contributing to Highly Pathogenic Avian Influenza H5N6 in China, 2014-2021: Based on a MaxEnt Model
    Sun, Zhuo
    Li, Yue-peng
    An, Qi
    Gao, Xiang
    Wang, Hong-bin
    TRANSBOUNDARY AND EMERGING DISEASES, 2023, 2023
  • [44] Molecular Characterization of Highly Pathogenic Avian Influenza Viruses H5N6 Detected in Denmark in 2018-2019
    Liang, Yuan
    Krog, Jesper Schak
    Ryt-Hansen, Pia
    Pedersen, Anders Gorm
    Kvisgaard, Lise Kirstine
    Holm, Elisabeth
    Nielsen, Pernille Dahl
    Hammer, Anne Sofie
    Madsen, Jesper Johannes
    Thorup, Kasper
    Larsen, Lars Erik
    Hjulsager, Charlotte Kristiane
    VIRUSES-BASEL, 2021, 13 (06):
  • [45] Isolation of highly pathogenic H5N6 avian influenza virus in Southern Vietnam with genetic similarity to those infecting humans in China
    Tsunekuni, Ryota
    Sudo, Kasumi
    Phuong Thanh Nguyen
    Bach Duc Luu
    Thai Duy Phuong
    Tran Minh Tan
    Tung Nguyen
    Mine, Junki
    Nakayama, Momoko
    Tanikawa, Taichiro
    Sharshov, Kirill
    Takemae, Nobuhiro
    Saito, Takehiko
    TRANSBOUNDARY AND EMERGING DISEASES, 2019, 66 (06) : 2209 - 2217
  • [46] Identification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016
    Jeong, Jipseol
    Woo, Chanjin
    Ip, Hon S.
    An, Injung
    Kim, Youngsik
    Lee, Kwanghee
    Jo, Seong-Deok
    Son, Kidong
    Lee, Saemi
    Oem, Jae-Ku
    Wang, Seung-Jun
    Kim, Yongkwan
    Shin, Jeonghwa
    Sleeman, Jonathan
    Jheong, Weonhwa
    VIROLOGY JOURNAL, 2017, 14
  • [47] Identification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016
    Jipseol Jeong
    Chanjin Woo
    Hon S. Ip
    Injung An
    Youngsik Kim
    Kwanghee Lee
    Seong-Deok Jo
    Kidong Son
    Saemi Lee
    Jae-Ku Oem
    Seung-Jun Wang
    Yongkwan Kim
    Jeonghwa Shin
    Jonathan Sleeman
    Weonhwa Jheong
    Virology Journal, 14
  • [48] Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China
    Jiang, Hui
    Wu, Peng
    Uyeki, Timothy M.
    He, Jianfeng
    Deng, Zhihong
    Xu, Wen
    Lv, Qiang
    Zhang, Jin
    Wu, Yang
    Tsang, Tim K.
    Kang, Min
    Zheng, Jiandong
    Wang, Lili
    Yang, Bingyi
    Qin, Ying
    Feng, Luzhao
    Fang, Vicky J.
    Gao, George F.
    Leung, Gabriel M.
    Yu, Hongjie
    Cowling, Benjamin J.
    CLINICAL INFECTIOUS DISEASES, 2017, 65 (03) : 383 - 388
  • [49] Pathogenicity and genetic characterisation of a novel reassortant, highly pathogenic avian influenza (HPAI) H5N6 virus isolated in Korea, 2017
    Kim, Young-Il
    Si, Young-Jae
    Kwon, Hyeok-Il
    Kim, Eun-Ha
    Park, Su-Jin
    Robles, Norbert John
    Hiep Dinh Nguyen
    Yu, Min-Ah
    Yu, Kwang-Min
    Lee, Youn-Jeong
    Lee, Myoung-Heon
    Choi, Young Ki
    EUROSURVEILLANCE, 2018, 23 (07): : 8 - 15
  • [50] Reassortant Highly Pathogenic H5N6 Avian Influenza Virus Containing Low Pathogenic Viral Genes in a Local Live Poultry Market, Vietnam
    Tran Bac Le
    Van Phan Le
    Lee, Ji-Eun
    Kang, Jung-Ah
    Thi Bich Ngoc Trinh
    Lee, Hyeok Won
    Jeong, Dae Gwin
    Yoon, Sun-Woo
    CURRENT MICROBIOLOGY, 2021, 78 (11) : 3835 - 3842
12345