New Reassortant H5N6 Highly Pathogenic Avian Influenza Viruses in Southern China, 2014

被引：19
|
作者：
Jiao, Peirong [1 ,2 ,3 ,4 ]
Cui, Jin [1 ,2 ,3 ,4 ]
Song, Yafen [1 ,2 ,3 ,4 ]
Song, Hui [1 ,2 ,3 ,4 ]
Zhao, Zhishan [1 ,5 ]
Wu, Siyu [1 ,2 ,3 ,4 ]
Qu, Nannan [1 ,2 ,3 ,4 ]
Wang, Nianchen [1 ,2 ,3 ,4 ]
Ouyang, Guowen [1 ,2 ,3 ,4 ]
Liao, Ming [1 ,2 ,3 ,4 ]
机构：
[1] Natl & Reg Joint Engn Lab Medicament Zoonosis Pre, Guangzhou, Guangdong, Peoples R China
[2] Minist Agr, Key Lab Anim Vaccine Dev, Guangzhou, Guangdong, Peoples R China
[3] Key Lab Zoonosis Prevent & Control Guangdong, Guangzhou, Guangdong, Peoples R China
[4] South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China
[5] South China Agr Univ, Coll Life Sci, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2016年 / 7卷
基金：
中国国家自然科学基金;
关键词：
H5N6; highly pathogenic avian influenza virus; ducks; evolution; pathogenicity; A-VIRUSES; HEMAGGLUTININ; POLYMERASE; DUCKS;
D O I：
10.3389/fmicb.2016.00754
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
New reassortant H5N6 highly pathogenic avian influenza viruses (AlVs) were isolated from apparently healthy domestic ducks in Southern China in 2014. Our results show that the viruses grew efficiently in eggs and replicated systemically in chickens. They were completely lethal in chicken (100% mortality), and the mean death time was 6 to 7 days post-inoculation. The viruses could transmit in chickens by naive contact. BLAST analysis revealed that their HA gene was most closely related to A/wild duck/Shangdong/628/2011 (H5N1), and their NA genes were most closely related to A/swine/Guangdong/K6/2010 (H6N6). The other genes had the highest identity with A/wild duck/Fujian/1/2011(H5N1). The results of phylogenetic analysis showed that their HA genes clustered into Glade 2.3.4.4 of the H5N1 viruses and all genes derived from H5 were Mix-like or H6-like viruses. Thus, the new H5N6 viruses were reassortmented of H5N1 and H6N6 virus. Therefore, the circulation of the new H5N6 AlVs may become a threat to poultry and human health.
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页数：12
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