T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils

被引：12
|
作者：
Samadi, Nazanin [1 ]
Polak, Dominika [1 ]
Kitzmueller, Claudia [1 ]
Steinberger, Peter [2 ]
Zlabinger, Gerhard J. [2 ]
Jahn-Schmid, Beatrice [1 ]
Bohle, Barbara [1 ]
机构：
[1] Med Univ Vienna, Dept Pathophysiol & Allergy Res, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Immunol, Vienna, Austria
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2019年 / 49卷 / 09期
基金：
奥地利科学基金会;
关键词：
Allergen-specific T cells; Allergy; Neutrophils; Th1; Th2; CD4(+);
D O I：
10.1002/eji.201848057
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.
引用
收藏
页码：1441 / 1443
页数：3
相关论文
共 50 条
  • [41] ANALYSIS OF FUNCTION OF A HUMAN ANTIGEN-PRESENTING CELL BY XENOGENEIC INTERACTION WITH MOUSE T-CELLS
    TSUNETSUGUYOKOTA, Y
    MIZUOCHI, T
    HASHIMOTO, H
    SZIKARADKIEWICZ, A
    YAGITA, H
    YANO, A
    TAKEMORI, T
    IMMUNOLOGY LETTERS, 1994, 40 (01) : 73 - 77
  • [42] RESTRICTION MOLECULES INVOLVED IN THE INTERACTION OF HUMAN T-CELL CLONES WITH ANTIGEN-PRESENTING CELLS
    KOIDE, Y
    YOSHIDA, TO
    IMMUNOLOGY LETTERS, 1984, 7 (04) : 209 - 213
  • [43] A Suppressor of Cytokine Signaling 1 Antagonist Enhances Antigen-Presenting Capacity and Tumor Cell Antigen-Specific Cytotoxic T Lymphocyte Responses by Human Monocyte-Derived Dendritic Cells
    Wang, Yongjun
    Wang, Shengyu
    Ding, Yuan
    Ye, Yanhua
    Xu, Yingyi
    He, Huixiang
    Li, Qiaozhen
    Mi, Yanjun
    Guo, Chunhua
    Lin, Zhicai
    Liu, Tao
    Zhang, Yaya
    Chen, Yuqiang
    Yan, Jianghua
    CLINICAL AND VACCINE IMMUNOLOGY, 2013, 20 (09) : 1449 - 1456
  • [44] Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function
    Cua, DJ
    Coffman, RL
    Stohlman, SA
    JOURNAL OF IMMUNOLOGY, 1996, 157 (07): : 2830 - 2836
  • [45] HUMAN MYOBLASTS AS ANTIGEN-PRESENTING CELLS
    GOEBELS, N
    MICHAELIS, D
    WEKERLE, H
    HOHLFELD, R
    JOURNAL OF IMMUNOLOGY, 1992, 149 (02): : 661 - 667
  • [46] ANTIGEN-PRESENTING CELL-TYPES
    KNIGHT, SC
    STAGG, AJ
    CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (03) : 374 - 382
  • [47] EFFECT OF UVB ON ALLOACTIVATING AND ANTIGEN-PRESENTING CAPACITY OF HUMAN EPIDERMAL LANGERHANS CELLS
    AUSTAD, J
    BRAATHEN, LR
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1985, 21 (05) : 417 - 423
  • [48] DOES T-CELL TOLERANCE REQUIRE A DEDICATED ANTIGEN-PRESENTING CELL
    MATZINGER, P
    GUERDER, S
    NATURE, 1989, 338 (6210) : 74 - 76
  • [49] Molecular associations and microdomains in antigen-presenting cell-T-cell interactions
    Triantafilou, K
    Triantafilou, M
    Fernandez, N
    CRITICAL REVIEWS IN IMMUNOLOGY, 2000, 20 (05) : 359 - 373
  • [50] T Cell Antigen Discovery using Signaling and Antigen-presenting Bifunctional Receptors (SABRs)
    Joglekar, Alok
    Leonard, Michael Troy
    Jeppson, John
    Bethune, Michael T.
    Baltimore, David
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
12345