T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils

被引：12
|
作者：
Samadi, Nazanin [1 ]
Polak, Dominika [1 ]
Kitzmueller, Claudia [1 ]
Steinberger, Peter [2 ]
Zlabinger, Gerhard J. [2 ]
Jahn-Schmid, Beatrice [1 ]
Bohle, Barbara [1 ]
机构：
[1] Med Univ Vienna, Dept Pathophysiol & Allergy Res, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Immunol, Vienna, Austria
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2019年 / 49卷 / 09期
基金：
奥地利科学基金会;
关键词：
Allergen-specific T cells; Allergy; Neutrophils; Th1; Th2; CD4(+);
D O I：
10.1002/eji.201848057
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.
引用
收藏
页码：1441 / 1443
页数：3
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