Modified peptides from a water bloom of the cyanobacterium Nostoc sp.

被引：53
|
作者：
Ploutno, A [1 ]
Carmeli, S [1 ]
机构：
[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel
来源：
TETRAHEDRON | 2002年 / 58卷 / 50期
关键词：
cyanobacteria; Nostoc; protease inhibitors; cyclichexapeptides;
D O I：
10.1016/S0040-4020(02)01326-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Six new metabilites, nostopeptin BN920 (1), nostoginin BN741 (2), nostoginin BN578 (3), banyascyclamide A (4) banyascyclamide B (5) and banyascyclamide C (6), were isolated from the hydrophilic extract of a Nostoc sp. The planar structure of compounds 1-6 was determined by homonuclear and inverse-heteronuclear 2D NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centers was studied using Marfey's method for HPLC. Compound 1 inhibits the serine-protease chymotrypsin while compound 2 inhibits amino-proteases. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9949 / 9957
页数：9
相关论文
共 50 条
  • [1] Banyasin A and banyasides A and B, three novel modified peptides from a water bloom of the cyanobacterium Nostoc sp.
    Pluotno, A
    Carmeli, S
    TETRAHEDRON, 2005, 61 (03) : 575 - 583
  • [2] Micropeptins from an Israeli Fishpond Water Bloom of the Cyanobacterium Microcystis sp.
    Zafrir, Ella
    Carmeli, Shmuel
    JOURNAL OF NATURAL PRODUCTS, 2010, 73 (03): : 352 - 358
  • [3] Two new microcyclamides from a water bloom of the cyanobacterium Microcystis sp.
    Zafrir-Ilan, Ella
    Carmeli, Shmuel
    TETRAHEDRON LETTERS, 2010, 51 (50) : 6602 - 6604
  • [4] A novel α-amylase from the cyanobacterium Nostoc sp. PCC 7119
    Francisco M. Reyes-Sosa
    Fernando P. Molina-Heredia
    Miguel A. De la Rosa
    Applied Microbiology and Biotechnology, 2010, 86 : 131 - 141
  • [5] Cylindrocyclophanes with Proteasome Inhibitory Activity from the Cyanobacterium Nostoc sp.
    Chlipala, George E.
    Sturdy, Megan
    Krunic, Aleksej
    Lantvit, Daniel D.
    Shen, Qi
    Porter, Kyle
    Swanson, Steven M.
    Orjala, Jimmy
    JOURNAL OF NATURAL PRODUCTS, 2010, 73 (09): : 1529 - 1537
  • [6] Nostocyclyne A, a novel antimicrobial cyclophane from the cyanobacterium Nostoc sp.
    Ploutno, A
    Carmeli, S
    JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11): : 1524 - 1526
  • [7] Two novel biological active modified peptides from the cyanobacterium Microcystis sp.
    Raveh, A.
    Carmeli, S.
    PHYTOCHEMISTRY LETTERS, 2009, 2 (01) : 10 - 14
  • [8] Three novel metabolites from a bloom of the cyanobacterium Microcystis sp.
    Gesner-Apter, Shiri
    Carmeli, Shmuel
    TETRAHEDRON, 2008, 64 (28) : 6628 - 6634
  • [9] Structural features of the bioactive cyanobacterium Nostoc sp. exopolysaccharide
    Uhliarikova, Iveta
    Matulova, Maria
    Capek, Peter
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 : 2284 - 2292
  • [10] Merocyclophanes A and B, antiproliferative cyclophanes from the cultured terrestrial Cyanobacterium Nostoc sp.
    Kang, Hahk-Soo
    Santarsiero, Bernard D.
    Kim, Hyunjung
    Krunic, Aleksej
    Shen, Qi
    Swanson, Steven M.
    Chai, Heebyung
    Kinghorn, A. Douglas
    Orjala, Jimmy
    PHYTOCHEMISTRY, 2012, 79 : 109 - 115
12345