4-N-aryl(benzyl)amino-4-hetaryl-1-butenes as building blocks in heterocyclic synthesis.: 3.: A simple synthesis of fluorinated 4-methyl-2-(3-pyridyl)-1,2,3,4-tetrahydroquinolines and their respective quinolines

被引：0

作者：

Méndez, LYV ^{[1
]}

Kouznetsov, V ^{[1
]}

机构：

[1] Univ Santander, Sch Chem, Res Ctr Biomol, Lab Fine Organ Synth, Bucaramanga, Colombia

来源：

HETEROCYCLIC COMMUNICATIONS | 2002年 / 8卷 / 06期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Fluoro- and 6,8-difluro-4-methyl-2-(3-pyridyl)-1,2,3,4-tetrahydroquinolines (5,6) and their respective quinolines (7,8) were obtained by a two or three step synthesis, starting from the corresponding aldimines (1,2) preformed from 4-fluoro- or 2,4-difluoroanilines and 3-pyridinecarboxaldehyde via a sequence of reactions that included nucleophilic addition of Grignard reagents to the aldimines and an acid-mediated intramolecular cyclisation of the homoallylamines with fluorinated substituents (3,4).

引用

页码：583 / 586

页数：4

共 50 条

[41] Synthesis of N-(4-methyl-1,2,3,4-tetrahydro-2 quinolinyl)-N-aryl amines
Piri, F
Zalfard, HA
Gahramani, A
Yavari, I
SYNTHETIC COMMUNICATIONS, 2005, 35 (08) : 1109 - 1113
[42] Synthesis and antimicrobial activity of 1-aryl-4-methyl (1,2,4) triazolo (4,3,a) quinoxalines
Vyas, DA
Chauhan, NA
Parikh, AR
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 14 (04) : 361 - 362
[43] SYNTHESIS OF 3-CYANO-6-METHYL-4-PYRIDYL AND 3-CYANO-4-METHYL-6-PYRIDYL-PYRID-2(1H)-ONES
HANFELD, V
LEISTNER, S
WAGNER, G
PHARMAZIE, 1988, 43 (11): : 762 - 764
[44] SYNTHESIS OF (2R,3S,4S)-4-AMINO-3-HYDROXY-2-METHYL-5-(3-PYRIDYL)-PENTANOIC ACID PRESENT IN ANTIBIOTIC PYRIDOMYCIN
KINOSHITA, M
MARIYAMA, S
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1975, 48 (07) : 2081 - 2083
[45] Synthesis and antiradical activity of 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones
Ivan V. Kulakov
Mariya V. Matsukevich
Zarina T. Shulgau
Shyngys Sergazy
Tulegen M. Seilkhanov
Amrit Puzari
Alexander S. Fisyuk
Chemistry of Heterocyclic Compounds, 2015, 51 : 991 - 996
[46] Synthesis of 3-aryl-5-methyl 4-substituted [1,2,4]triazoles
Lindstrom, Johan
Johansson, Martin H.
SYNTHETIC COMMUNICATIONS, 2006, 36 (15) : 2217 - 2229
[47] Enantioselective Synthesis of 4-Silyl-1,2,3,4-tetrahydroquinolines via Copper(I) Hydride Catalyzed Asymmetric Hydrosilylation of 1,2-Dihydroquinolines
Xu-Xu, Qing-Feng
Yang, Pusu
Zhang, Xiao
You, Shu-Li
SYNLETT, 2021, 32 (05) : 505 - 510
[48] SYNTHESIS OF 5-ARYL-3-(4-PYRIDYL)-1,2,4-OXADIAZOLES
BRANA, MF
CASTELLANO, JM
YUNTA, MJR
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (05) : 1403 - 1405
[49] Pd/Cu-catalyzed couplings of β-amino esters with aryl bromides.: Synthesis of chiral 1,2,3,4-tetrahydro-4-oxo-2-alkyl-1-quinolines
Ma, DW
Jiang, JQ
TETRAHEDRON-ASYMMETRY, 1998, 9 (07) : 1137 - 1142
[50] Thallium(III) salts in heterocyclic synthesis:: Synthesis of 3-aryl-9-methyl-1,2,4-triazolo[4,3-a]quinolines
Singh, OV
Muthukrishnan, M
Sundaravadivelu, M
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2001, 40 (03): : 262 - 265

← 1 2 3 4 5 →