4-N-aryl(benzyl)amino-4-hetaryl-1-butenes as building blocks in heterocyclic synthesis.: 3.: A simple synthesis of fluorinated 4-methyl-2-(3-pyridyl)-1,2,3,4-tetrahydroquinolines and their respective quinolines

被引：0
|
作者：
Méndez, LYV [1 ]
Kouznetsov, V [1 ]
机构：
[1] Univ Santander, Sch Chem, Res Ctr Biomol, Lab Fine Organ Synth, Bucaramanga, Colombia
来源：
HETEROCYCLIC COMMUNICATIONS | 2002年 / 8卷 / 06期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
6-Fluoro- and 6,8-difluro-4-methyl-2-(3-pyridyl)-1,2,3,4-tetrahydroquinolines (5,6) and their respective quinolines (7,8) were obtained by a two or three step synthesis, starting from the corresponding aldimines (1,2) preformed from 4-fluoro- or 2,4-difluoroanilines and 3-pyridinecarboxaldehyde via a sequence of reactions that included nucleophilic addition of Grignard reagents to the aldimines and an acid-mediated intramolecular cyclisation of the homoallylamines with fluorinated substituents (3,4).
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页码：583 / 586
页数：4
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