Anti-osteosarcoma effect of novel pyran-annulated heterocycles derivatives.

被引：0
|
作者：
Bi, Qing [1 ]
Ruan, Wei-Wei [2 ]
Cao, Li [3 ]
Xu, You-Jia [4 ]
机构：
[1] Soochow Univ, Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China
[2] Wenzhou Med Univ, Dept Orthoped Surg, Wenzhou, Zhejiang, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Dept Orthopaed, Hangzhou, Zhejiang, Peoples R China
[4] Soochow Univ, Affiliated Hosp 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China
来源：
BIOMEDICAL RESEARCH-INDIA | 2017年 / 28卷 / 03期
关键词：
Pyran; Crystal; Anti-osteosarcom; ANTICANCER ACTIVITY;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The synthesis and characterization of four novel pyran derivatives (1-4) were realized by means of IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. The anti-osteosarcoma activities of the four compounds were investigated against three human osteoma sarcomatosum cells (HuO9, 143B and MG-63) by MTT assay. It has been found that compounds 3 and 4 exerted much more potent activities against the three cell lines than the other two compounds.
引用
收藏
页码：1290 / 1293
页数：4
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