Anti-osteosarcoma effect of novel pyran-annulated heterocycles derivatives.

被引：0

作者：

Bi, Qing ^{[1
]}

Ruan, Wei-Wei ^{[2
]}

Cao, Li ^{[3
]}

Xu, You-Jia ^{[4
]}

机构：

[1] Soochow Univ, Dept Orthoped Surg, Suzhou, Jiangsu, Peoples R China

[2] Wenzhou Med Univ, Dept Orthoped Surg, Wenzhou, Zhejiang, Peoples R China

[3] Zhejiang Prov Peoples Hosp, Dept Orthopaed, Hangzhou, Zhejiang, Peoples R China

[4] Soochow Univ, Affiliated Hosp 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China

来源：

BIOMEDICAL RESEARCH-INDIA | 2017年 / 28卷 / 03期

关键词：

Pyran; Crystal; Anti-osteosarcom; ANTICANCER ACTIVITY;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The synthesis and characterization of four novel pyran derivatives (1-4) were realized by means of IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. The anti-osteosarcoma activities of the four compounds were investigated against three human osteoma sarcomatosum cells (HuO9, 143B and MG-63) by MTT assay. It has been found that compounds 3 and 4 exerted much more potent activities against the three cell lines than the other two compounds.

引用

页码：1290 / 1293

页数：4

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