The nitric oxide/cGMP signaling pathway in pulmonary hypertension

被引：59
|
作者：
Klinger, James R.
机构：
[1] Rhode Isl Hosp, Div Pulm Sleep & Crit Care Med, Providence, RI 02903 USA
[2] Brown Univ, Sch Med, Providence, RI 02912 USA
来源：
CLINICS IN CHEST MEDICINE | 2007年 / 28卷 / 01期
关键词：
D O I：
10.1016/j.ccm.2006.12.002
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
This article briefly reviews the background of endothelium-dependent vasorelaxation, describes the nitric oxide/cGMP/protein kinase pathway and its role in modulating pulmonary vascular tone and remodeling, and describes three approaches that target the nitric oxide/cGMP pathway in the treatment of patients with pulmonary arterial hypertension.
引用
收藏
页码：143 / +
页数：26
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