The nitric oxide/cGMP signaling pathway in pulmonary hypertension

被引：59
|
作者：
Klinger, James R.
机构：
[1] Rhode Isl Hosp, Div Pulm Sleep & Crit Care Med, Providence, RI 02903 USA
[2] Brown Univ, Sch Med, Providence, RI 02912 USA
来源：
CLINICS IN CHEST MEDICINE | 2007年 / 28卷 / 01期
关键词：
D O I：
10.1016/j.ccm.2006.12.002
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
This article briefly reviews the background of endothelium-dependent vasorelaxation, describes the nitric oxide/cGMP/protein kinase pathway and its role in modulating pulmonary vascular tone and remodeling, and describes three approaches that target the nitric oxide/cGMP pathway in the treatment of patients with pulmonary arterial hypertension.
引用
收藏
页码：143 / +
页数：26
相关论文
共 50 条
  • [31] Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics
    Sparacino-Watkins, Courtney E.
    Lai, Yen-Chun
    Gladwin, Mark T.
    CIRCULATION, 2012, 125 (23) : 2824 - 2826
  • [32] Nitric oxide donors and pulmonary hypertension
    Elmedal, B.
    Andersen, C. U.
    Mulvany, M. J.
    Simonsen, U.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18 : 18 - 18
  • [33] The nitric oxide signaling pathway in the penis
    Burnett, AL
    Musicki, B
    CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (31) : 3987 - 3994
  • [34] Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep
    Deruelle, P
    Grover, TR
    Abman, SH
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2005, 289 (05) : L798 - L806
  • [35] Nitric Oxide Signaling in the Auditory Pathway
    Kopp-Scheinpflug, Conny
    Forsythe, Ian D.
    FRONTIERS IN NEURAL CIRCUITS, 2021, 15
  • [36] Nitric oxide in systemic and pulmonary hypertension
    Chen, HI
    Hu, CT
    Wu, CY
    Wang, D
    JOURNAL OF BIOMEDICAL SCIENCE, 1997, 4 (05) : 244 - 248
  • [37] The nitric oxide-soluble guanylate cyclase-cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase
    Benza, Raymond L.
    Gruenig, Ekkehard
    Sandner, Peter
    Stasch, Johannes -Peter
    Simonneau, Gerald
    EUROPEAN RESPIRATORY REVIEW, 2024, 33 (171):
  • [38] Alendronate induces gastric damage by reducing nitric oxide synthase expression and NO/cGMP/KATP signaling pathway
    Silva, Renan O.
    Lucetti, Larisse T.
    Wong, Deysi V. T.
    Aragao, Karoline S.
    Junior, Eudmar M. A.
    Soares, Pedro M. G.
    Barbosa, Andre Luiz R.
    Ribeiro, Ronaldo A.
    Souza, Marcellus H. L. P.
    Medeiros, Jand-Venes R.
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 40 : 22 - 30
  • [39] The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine
    Ozdemir, Ercan
    Bagcivan, Ihsan
    Durmus, Nedim
    Altun, Ahmet
    Gursoy, Sinan
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2011, 89 (02) : 89 - 95
  • [40] Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes
    Loredana Bergandi
    Marco Cordero
    Matteo Anselmino
    Gaetana Ferraro
    Laura Ravera
    Paola Dalmasso
    Corrado Moiraghi
    Gian Paolo Trevi
    Dario Ghigo
    Amalia Bosia
    Serena Bergerone
    Clinical Research in Cardiology, 2010, 99 : 557 - 564
12345