The nitric oxide/cGMP signaling pathway in pulmonary hypertension

被引：59
|
作者：
Klinger, James R.
机构：
[1] Rhode Isl Hosp, Div Pulm Sleep & Crit Care Med, Providence, RI 02903 USA
[2] Brown Univ, Sch Med, Providence, RI 02912 USA
来源：
CLINICS IN CHEST MEDICINE | 2007年 / 28卷 / 01期
关键词：
D O I：
10.1016/j.ccm.2006.12.002
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
This article briefly reviews the background of endothelium-dependent vasorelaxation, describes the nitric oxide/cGMP/protein kinase pathway and its role in modulating pulmonary vascular tone and remodeling, and describes three approaches that target the nitric oxide/cGMP pathway in the treatment of patients with pulmonary arterial hypertension.
引用
收藏
页码：143 / +
页数：26
相关论文
共 50 条
  • [1] Nitric Oxide-cGMP Pathway Modulation in an Experimental Model of Hypoxic Pulmonary Hypertension
    Reinero, Melanie
    Beghetti, Maurice
    Tozzi, Piergiorgio
    von Segesser, Ludwig K.
    Samaja, Michele
    Milano, Giuseppina
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2021, 26 (06) : 665 - 676
  • [2] Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension
    Tang, Haiyang
    Vanderpool, Rebecca R.
    Wang, Jian
    Yuan, Jason X. -J.
    PULMONARY CIRCULATION, 2017, 7 (03) : 569 - 571
  • [3] Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain
    Li, Dan-Yang
    Gao, Shao-Jie
    Sun, Jia
    Zhang, Long-Qing
    Wu, Jia-Yi
    Song, Fan-He
    Liu, Dai-Qiang
    Zhou, Ya-Qun
    Mei, Wei
    NEURAL REGENERATION RESEARCH, 2023, 18 (05) : 996 - 1003
  • [4] Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain
    Dan-Yang Li
    Shao-Jie Gao
    Jia Sun
    Long-Qing Zhang
    Jia-Yi Wu
    Fan-He Song
    Dai-Qiang Liu
    Ya-Qun Zhou
    Wei Mei
    Neural Regeneration Research, 2023, 18 (05) : 996 - 1003
  • [5] Nitric Oxide-cGMP Signaling in Hypertension Current and Future Options for Pharmacotherapy
    Ataei Ataabadi, Ehsan
    Golshiri, Keivan
    Juttner, Annika
    Krenning, Guido
    Danser, A. H. Jan
    Roks, Anton J. M.
    HYPERTENSION, 2020, 76 (04) : 1055 - 1068
  • [6] Glycine and GABA interact to regulate the nitric oxide/cGMP signaling pathway in retina
    Eldred, WD
    Yu, D
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
  • [7] Nesiritide acutely increases pulmonary and systemic levels of nitric oxide and cGMP in pulmonary hypertension patients
    Michaels, AD
    Harmon, CT
    Johengen, M
    Fineman, J
    Chatterjee, K
    De Marco, T
    CIRCULATION, 2004, 110 (17) : 555 - 556
  • [8] Thrombin Has Biphasic Effects on the Nitric Oxide-cGMP Pathway in Endothelial Cells and Contributes to Experimental Pulmonary Hypertension
    Nickel, Katrin F.
    Laux, Volker
    Heumann, Rolf
    von Degenfeld, Georges
    PLOS ONE, 2013, 8 (06):
  • [9] Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension
    Ghofrani, HA
    Pepke-Zaba, J
    Barbera, JA
    Channick, R
    Keogh, AM
    Gomez-Sanchez, MA
    Kneussl, M
    Grimminger, F
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (12) : 68S - 72S
  • [10] Therapy for Pulmonary Arterial Hypertension: Glance on Nitric Oxide Pathway
    Tettey, Abraham
    Jiang, Yujie
    Li, Xiaohui
    Li, Ying
    FRONTIERS IN PHARMACOLOGY, 2021, 12
12345