Renal repair: role of bone marrow stem cells

被引：11
|
作者：
Lin, Fangming [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA
来源：
PEDIATRIC NEPHROLOGY | 2008年 / 23卷 / 06期
关键词：
stem cells; renal ischemia-reperfusion injury; renal repair; stem cell mobilization; cell conversion;
D O I：
10.1007/s00467-007-0634-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Acute kidney injury carries severe consequences and has limited treatment options. Bone marrow stem cells may offer the potential for treatment of acute kidney injury. The purpose of this review is twofold. The first purpose is to provide a concise overview of the biology of bone marrow stem cells, including hematopoietic stem cells and mesenchymal stem cells, for clinical nephrologists and renal researchers. The second purpose is to summarize published data regarding the role of bone marrow stem cells in renal repair after acute kidney injury. Currently, much of our knowledge of renal protective effect of bone marrow stem cells is obtained through animal research. Our goal is to understand the mechanism of renal protection by bone marrow stem cells and to develop strategies utilizing these stem cells for the eventual treatment of humans with kidney disease.
引用
收藏
页码：851 / 861
页数：11
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