Germ Cell Tumors: Insights From the Drosophila Ovary and the Mouse Testis

被引：11
|
作者：
Salz, Helen K. [1 ]
Dawson, Emily P. [2 ]
Heaney, Jason D. [2 ]
机构：
[1] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA
[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
来源：
MOLECULAR REPRODUCTION AND DEVELOPMENT | 2017年 / 84卷 / 03期
基金：
美国国家卫生研究院;
关键词：
CONGENITAL TESTICULAR TERATOMAS; CARCINOMA IN-SITU; BAG-OF-MARBLES; STEM-CELL; SELF-RENEWAL; SEX DETERMINATION; EMBRYONIC-DEVELOPMENT; SUSCEPTIBILITY LOCI; JAK/STAT PATHWAY; DIFFERENTIATION;
D O I：
10.1002/mrd.22779
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which evidence supports common underlying mechanisms, such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. Wethen discuss how these concepts inform our understanding of the disease in humans.
引用
收藏
页码：200 / 211
页数：12
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