Inhibition of Fibroblast Growth Factor-23 (FGF-23) Rescues Bone and Hematopoietic Stem Cell Niche Defects in BetaThalassemia, Uncovering the Missing Link between Hematopoiesis and Bone

被引：1

作者：

Aprile, Annamaria ^{[1
]}

Raggi, Laura ^{[1
]}

Bolamperti, Simona ^{[2
]}

Storto, Mariangela ^{[1
]}

Villa, Isabella ^{[2
]}

Morello, Gaia ^{[3
]}

Marktel, Sarah ^{[4
]}

Tripodo, Claudio ^{[3
]}

Motta, Irene ^{[5
,6
]}

Cappellini, Maria Domenica ^{[5
,6
]}

Rubinacci, Alessandro

Ferrari, Giuliana ^{[7
]}

机构：

[1] IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy SR Tiget, Milan, Italy

[2] IRCCS San Raffaele Sci Inst, Osteoporosis & Bone & Mineral Metab Unit, Milan, Italy

[3] Univ Palermo, Human Pathol Sect, Dept Hlth Sci, Tumor Immunol Unit, Palermo, Italy

[4] IRCCS San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[5] Univ Milan, Dept Clin Sci & Community, Milan, Italy

[6] IRCCS Ca Granda Fdn, Maggiore Policlin Hosp, Milan, Italy

[7] Univ Vita Salute San Raffaele, Milan, Italy

来源：

BLOOD | 2021年 / 138卷

关键词：

D O I：

10.1182/blood-2021-148366

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

572

引用

页数：3

共 21 条

[11] FIBROBLAST GROWTH FACTOR-23 PROMOTES OSTEOBLAST DIFFERENTIATION IN BONE-DERIVED MESENCHYMAL STEM CELLS
He, X.
Li, Y.
Olauson, H.
Lindgren, U.
Larsson, T. E.
OSTEOPOROSIS INTERNATIONAL, 2011, 22 : S701 - S702
[12] THE ASSOCIATIONS OF FIBROBLAST GROWTH FACTOR 23 (FGF-23) WITH KNOWN MARKERS OF CHRONIC KIDNEY DISEASE MINERAL AND BONE DISORDER (CKD-MBD)
Damasiewicz, M.
Kerr, P.
Lu, Z.
Polkinghorne, K.
NEPHROLOGY, 2014, 19 : 22 - 22
[13] Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men
Marsell, R.
Mirza, M. A. I.
Mallmin, H.
Karlsson, M.
Mellstrom, D.
Orwoll, E.
Ohlsson, C.
Jonsson, K. B.
Ljunggren, O.
Larsson, T. E.
OSTEOPOROSIS INTERNATIONAL, 2009, 20 (07) : 1167 - 1173
[14] Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men
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H. Mallmin
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D. Mellström
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C. Ohlsson
K. B. Jonsson
Ö. Ljunggren
T. E. Larsson
Osteoporosis International, 2009, 20 : 1167 - 1173
[15] Fibroblast Growth Factor 23 Neutralizing Antibody Partially Rescues Bone Loss in Sickle Cell Disease Mice
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He, Wei
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JOURNAL OF BONE AND MINERAL RESEARCH, 2024, 39 : 384 - 384
[16] Relationship between Plasma Fibroblast Growth Factor-23 Concentration and Bone Mineralization in Children with Renal Failure on Peritoneal Dialysis
Wesseling-Perry, Katherine
Pereira, Renata C.
Wang, Hejing
Elashoff, Robert M.
Sahney, Shobha
Gales, Barbara
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Salusky, Isidro B.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (02): : 511 - 517
[17] The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis
Martiniakova, Monika
Mondockova, Vladimira
Biro, Roman
Kovacova, Veronika
Babikova, Martina
Zemanova, Nina
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FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[18] Correlation between serum levels of Fibroblast Growth Factor-23 (FGF-23) and parathyroid hormone levels in predialysis Chronic Kidney Disease (CKD) patients at Sanglah General Hospital, Bali, Indonesia
Worung, Ivan Master
Lestari, Anak Agung Wiradewi
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BALI MEDICAL JOURNAL, 2021, 10 (02) : 830 - 834
[19] Fibroblast growth factor 23 neutralizing antibody partially rescues bone loss and increases hematocrit in sickle cell disease mice
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SCIENTIFIC REPORTS, 2025, 15 (01):
[20] Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?
Wyatt, Christina M.
Drueeke, Tilman B.
KIDNEY INTERNATIONAL, 2016, 89 (01) : 7 - 9

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