Inhibition of Fibroblast Growth Factor-23 (FGF-23) Rescues Bone and Hematopoietic Stem Cell Niche Defects in BetaThalassemia, Uncovering the Missing Link between Hematopoiesis and Bone

被引：1

作者：

Aprile, Annamaria ^{[1
]}

Raggi, Laura ^{[1
]}

Bolamperti, Simona ^{[2
]}

Storto, Mariangela ^{[1
]}

Villa, Isabella ^{[2
]}

Morello, Gaia ^{[3
]}

Marktel, Sarah ^{[4
]}

Tripodo, Claudio ^{[3
]}

Motta, Irene ^{[5
,6
]}

Cappellini, Maria Domenica ^{[5
,6
]}

Rubinacci, Alessandro

Ferrari, Giuliana ^{[7
]}

机构：

[1] IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy SR Tiget, Milan, Italy

[2] IRCCS San Raffaele Sci Inst, Osteoporosis & Bone & Mineral Metab Unit, Milan, Italy

[3] Univ Palermo, Human Pathol Sect, Dept Hlth Sci, Tumor Immunol Unit, Palermo, Italy

[4] IRCCS San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[5] Univ Milan, Dept Clin Sci & Community, Milan, Italy

[6] IRCCS Ca Granda Fdn, Maggiore Policlin Hosp, Milan, Italy

[7] Univ Vita Salute San Raffaele, Milan, Italy

来源：

BLOOD | 2021年 / 138卷

关键词：

D O I：

10.1182/blood-2021-148366

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

572

引用

页数：3

共 21 条

[1] Inhibition of Fibroblast Growth Factor-23 (FGF-23) As a Novel Strategy to Target Bone and Hematopoietic Stem Cell Niche Defects in Beta-Thalassemia
Aprile, Annamaria
Raggi, Laura
Storto, Mariangela
Villa, Isabella
Marktel, Sarah
Motta, Irene
Cappellini, Maria Domenica
Rubinacci, Alessandro
Ferrari, Giuliana
BLOOD, 2020, 136
[2] Increased serum fibroblast growth factor-23 (FGF-23) and bone turnover in patients with osteoarthritis of knee
Zhou, Wu
Liu, Guo-Hui
Yang, Shu-Hua
Ye, Shu-Nan
Wang, Jing
Liu, Xian-Zhe
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (02): : 1630 - 1638
[3] Frequent Expression of Fibroblast Growth Factor-23 (FGF-23) mRNA in Aneurysmal Bone Cyst (ABC).
Krishnamurthy, S.
Inwards, C. Y.
Oliveira, A. M.
Folpe, A. L.
MODERN PATHOLOGY, 2011, 24 : 17A - 17A
[4] Frequent Expression of Fibroblast Growth Factor-23 (FGF-23) mRNA in Aneurysmal Bone Cyst (ABC)
Krishnamurthy, S.
Inwards, C. Y.
Oliveira, A. M.
Folpe, A. L.
LABORATORY INVESTIGATION, 2011, 91 : 17A - 17A
[5] THE RELATIONSHIP BETWEEN FIBROBLAST GROWTH FACTOR-23 (FGF-23) AND SELECTED CLINICAL AND LABORATORY PARAMETERS
Fedak, Danuta
Kuzniewski, Marek
Krzanowski, Marcin
Dumnicka, Paulina
Sulowicz, Wladyslaw
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2017, 32 : 648 - +
[6] The potential role of Fibroblast Growth Factor-23 (FGF-23) in Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD).
Manghat, P.
Cheung, J.
MacDonald, D.
Goldsmith, D. J. A.
Fogelman, I.
Weirzbicki, A. S.
Hampson, G.
JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S510 - S510
[7] Relationship of Fibroblast Growth Factor 23 (FGF-23) Serum Levels With Low Bone Mass in Postmenopausal Women
Shen, Jun
Fu, Shiping
Song, Yuan
JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (12) : 4454 - 4459
[8] Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas
Graham, Rondell
Krishnamurthy, Smita
Oliveira, Andre
Inwards, Carrie
Folpe, Andrew L.
JOURNAL OF CLINICAL PATHOLOGY, 2012, 65 (10) : 907 - 909
[9] Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia
Aprile, Annamaria
Raggi, Laura
Bolamperti, Simona
Villa, Isabella
Storto, Mariangela
Morello, Gaia
Marktel, Sarah
Tripodo, Claudio
Cappellini, Maria Domenica
Motta, Irene
Rubinacci, Alessandro
Ferrari, Giuliana
SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (698)
[10] EXPRESSION OF FIBROBLAST GROWTH FACTOR 23 (FGF-23), VITAMIN D RECEPTOR (VDR) AND SCLEROSTIN IN BONE TISSUE OF HYPERCALCIURIC STONE FORMERS
Alves, Maria Teresa
Moyses, Rosa Maria
Jorgetti, Vanda
Heilberg, Ita
Menon, Viviane
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 387 - 388

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