Tools for adaptive immune receptor repertoire sequencing

被引：3

作者：

Lees, William D. ^{[1
]}

机构：

[1] Birkbeck Coll, Inst Struct & Mol Biol, Malet St, London WC1E 7HX, England

来源：

CURRENT OPINION IN SYSTEMS BIOLOGY | 2020年 / 24卷

关键词：

Antibody repertoire sequencing; Immune receptor genes; AIRR-seq tools; Rep-seq tools; CLONALITY INFERENCE; T-CELL; IMMUNOGLOBULIN;

D O I：

10.1016/j.coisb.2020.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tools for adaptive immune receptor repertoire (AIRR) sequencing continue to evolve rapidly, and, although some established frameworks are emerging, there are no complete solutions: it is necessary to select tools and build a customised pipeline. Emerging trends of interest include standards for data interchange, tools for single-cell sequencing, genotyping, and tools that make use of probabilistic and structural inferences to identify receptor sequences of interest.

引用

页码：86 / 92

页数：7

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