Transplantation of allogenic cells in the therapy of patients with dilated cardiomyopathy

被引：9
|
作者：
Kirillov, A. M. [1 ]
Fatkhudinov, T. Kh. [1 ]
Dyachkov, A. V. [1 ]
Koroteev, A. V. [1 ]
Goldshtein, D. V. [1 ]
Bochkov, N. P. [1 ]
机构：
[1] ReMeTeks Co, Russian Acad Sci, B V Petrovskii Russian Res Surg Ctr, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 04期
关键词：
skeletal myoblasts; multipotent stromal cells; allogenic transplantation; dilated cardiomyopathy;
D O I：
10.1007/s10517-007-0392-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We carried out a pilot study on intracoronary transplantation of prenatal allogenic skeletal myoblasts and multipotent bone marrow stromal cells to patients with dilated cardiomyopathy. Intracoronary transplantation of allogenic cells is a feasible and safe procedure: there were no life-threatening rhythm and conduction disturbances, symptoms of hemodynamic instability, and thromboembolic complications. Positive clinical effect of cell transplantation persisted for 6 months and consisted in decreased content of brain natriuretic peptide and improved tolerance to physical exercises. We observed no reliable dynamics of the major echocardiographic parameters and their correlations with patient's status.
引用
收藏
页码：635 / 639
页数：5
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