Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum

被引：50
|
作者：
Harding, WW [1 ]
Tidgewell, K
Schmidt, M
Shah, K
Dersch, CM
Snyder, J
Parrish, D
Deschamps, JR
Rothman, RB
Prisinzano, TE
机构：
[1] Univ Iowa, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA
[2] NIDA, IRP, DHHS,Lab Struct Matter,Code 6030, Clin Psychopharmacol Sect,NIH, Baltimore, MD 21224 USA
[3] Naval Res Lab, Washington, DC USA
[4] Univ Iowa, High Field NMR Facil, Iowa City, IA 52242 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 14期
关键词：
D O I：
10.1021/ol0510522
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including H-1 and C-13 NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.
引用
收藏
页码：3017 / 3020
页数：4
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