Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum

被引：50

作者：

Harding, WW ^{[1
]}

Tidgewell, K

Schmidt, M

Shah, K

Dersch, CM

Snyder, J

Parrish, D

Deschamps, JR

Rothman, RB

Prisinzano, TE

机构：

[1] Univ Iowa, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] NIDA, IRP, DHHS,Lab Struct Matter,Code 6030, Clin Psychopharmacol Sect,NIH, Baltimore, MD 21224 USA

[3] Naval Res Lab, Washington, DC USA

[4] Univ Iowa, High Field NMR Facil, Iowa City, IA 52242 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 14期

关键词：

D O I：

10.1021/ol0510522

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including H-1 and C-13 NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.

引用

页码：3017 / 3020

页数：4

共 50 条

[21] NEW DITERPENES FROM SALVIA-PACHYSTACHYS
ULUBELEN, A
TUZLACI, E
JOURNAL OF NATURAL PRODUCTS, 1990, 53 (06): : 1597 - 1599
[22] NEOCLERODANE DITERPENES FROM CLERODENDRON-INERME
RAO, LJM
PEREIRA, J
GURUDUTT, KN
PHYTOCHEMISTRY, 1993, 34 (02) : 572 - 574
[23] The rise of a new psychoactive agent: Salvia divinorum
Appel J.
Kim-Appel D.
International Journal of Mental Health and Addiction, 2007, 5 (3) : 248 - 253
[24] Salvia divinorum - Representation of a new drug in the internet
Siemann, H.
Specka, M.
Schifano, F.
Deluca, P.
Scherbaum, N.
GESUNDHEITSWESEN, 2006, 68 (05) : 323 - 327
[25] Neo-clerodane diterpenes from the hallucinogenic sage Salvia divinorum (vol 69, pg 1782, 2006)
Shirota, Osamu
Nagamatsu, Kumi
Sekita, Setsuko
JOURNAL OF NATURAL PRODUCTS, 2007, 70 (02): : 328 - 328
[26] ABIETANE AND NEOCLERODANE DITERPENOIDS FROM SALVIA LAVANDULOIDES
MALDONADO, E
FLORES, MD
SALAZAR, B
ORTEGA, A
PHYTOCHEMISTRY, 1994, 37 (05) : 1480 - 1482
[27] NEOCLERODANE DITERPENOIDS FROM SALVIA-MADRENSIS
RODRIGUEZHAHN, L
ALVARADO, G
CARDENAS, J
ESQUIVEL, B
GAVINO, R
PHYTOCHEMISTRY, 1994, 35 (02) : 447 - 450
[28] Neoclerodane diterpenes from Amoora stellato-squamosa
Yang, SM
Wu, SH
Qin, XD
Luo, XD
Wu, DG
HELVETICA CHIMICA ACTA, 2004, 87 (05) : 1279 - 1286
[29] NEOCLERODANE TYPE DITERPENES FROM BACCHARIS-TRINERVIS
KUROYANAGI, M
UCHIDA, K
UENO, A
SATAKE, M
SHIMOMURA, K
PHYTOCHEMISTRY, 1993, 34 (05) : 1377 - 1384
[30] Three new diterpenes from the roots of Salvia miltiorrhiza and their cytotoxicity
Xia, Yi-Fan
Zheng, Jin-Hui
Li, Yan-Song
Yu, Ping
Liu, Zhe
Zhou, Jie
Fang, Lei
FITOTERAPIA, 2025, 181

← 1 2 3 4 5 →