Oral transmucosal fentanyl citrate for the treatment of breakthrough pain

被引：0
|
作者：
Zarth, R.
Ehmer, M.
Sittig, H. -B.
机构：
[1] Univ Tubingen, Akad Lehrkrankenhaus, Zollernalb Klinikum, Anaesthesiol & Intens Med Abt, D-72336 Balingen, Germany
[2] Praxis Schemerztherapie & Palliativ Med, Freiburg, Germany
[3] Spezielle Schmerztherapie Palliativ Med, MVZ Buntenskamp, Geesthacht, Germany
来源：
SCHMERZ | 2007年 / 21卷 / 06期
关键词：
cancer-related pain; breakthrough pain; oral transmucosal fentanyl citrate; observational study;
D O I：
10.1007/s00482-007-0590-z
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
In a non-interventional study the efficacy and tolerability of oral transmucosal fentanyl citrate (OTFC) was studied in patients with opioid-treated cancer pain suffering from breakthrough pain. The prospective multicenter observational trial included 406 patients. For 3-4 months, efficacy of OTFC treatment for breakthrough pain was documented using a numerical analog pain intensity scale (NAS). Further, OTFC therapy was rated and adverse events were recorded. With application of oral transmucosal fentanyl citrate median pain intensity fell from NAS 8 points at the beginning to NAS 2 points at the end of the study. The median effective dosage was 400 g. Tolerability was rated as good or very good by 87.5% of the patients. Oral transmucosal fentanyl citrate is a safe and effective treatment for breakthrough pain in chronic cancer-related pain.
引用
收藏
页码：545 / 552
页数：8
相关论文
共 50 条
  • [31] Breakthrough cancer pain:: a randomized trial comparing oral transmucosal fentanyl citrate (OTFC®) and morphine sulfate immediate release (MSIR®)
    Coluzzi, PH
    Schwartzberg, L
    Conroy, JD
    Charapata, S
    Gay, M
    Busch, MA
    Chavez, J
    Ashley, J
    Lebo, D
    McCracken, M
    Portenoy, RK
    PAIN, 2001, 91 (1-2) : 123 - 130
  • [32] Safety and Efficacy of Oral Transmucosal Fentanyl Citrate Compared to Morphine Sulphate Immediate Release Tablet in Management of Breakthrough Cancer Pain
    Bhatnagar, Sushma
    Devi, Saraswathi
    Vinod, N. K.
    Jain, P. N.
    Durgaprasad, G.
    Maroo, Sanjaykumar H.
    Patel, Ketan R.
    INDIAN JOURNAL OF PALLIATIVE CARE, 2014, 20 (03) : 182 - 187
  • [33] Pharmacokinetic and local tolerability profiles of three potential fentanyl nasal spray formulations developed for breakthrough cancer pain compared with oral transmucosal fentanyl citrate
    Taylor, D. R.
    Fisher, A. N.
    Smith, A.
    Watling, M.
    Knight, A.
    Gabrail, N. Y.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [34] ORAL TRANSMUCOSAL FENTANYL CITRATE - REPEATED DOSE PHARMACOKINETICS
    STREISAND, JB
    ROSENBERG, JA
    ASHBURN, MA
    KESSLER, KF
    EAST, KA
    KIEVIT, JK
    ZHANG, J
    PRICE, CL
    ANESTHESIOLOGY, 1993, 79 (3A) : A369 - A369
  • [35] ORAL TRANSMUCOSAL FENTANYL CITRATE FOR PREMEDICATION IN PEDIATRIC OUTPATIENTS
    ASHBURN, MA
    STREISAND, JB
    TARVER, SD
    MEARS, SL
    MULDER, SM
    FLOET, AW
    LUIJENDIJK, RW
    ELWYN, RA
    PACE, NL
    STANLEY, TH
    CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 1990, 37 (08): : 857 - 866
  • [36] Dose proportionality and pharmacokinetics of oral transmucosal fentanyl citrate
    Streisand, JB
    Busch, MA
    Egan, TD
    Smith, BG
    Gay, M
    Pace, NL
    ANESTHESIOLOGY, 1998, 88 (02) : 305 - 309
  • [37] Oral transmucosal fentanyl citrate -: OTFC (ACTIQ™) #103
    Gordon, Debra
    Schroeder, Mark
    JOURNAL OF PALLIATIVE MEDICINE, 2008, 11 (04) : 633 - 634
  • [38] Safety and Efficacy of Oral Transmucosal Fentanyl Citrate Compared to Morphine Sulphate Immediate Release Tablet in Management of Breakthrough Cancer Pain Commentary
    Deodhar, Jayita
    INDIAN JOURNAL OF PALLIATIVE CARE, 2014, 20 (03) : 187 - 188
  • [39] The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain
    Lichtor, JL
    Sevarino, FB
    Joshi, GP
    Busch, MA
    Nordbrock, E
    Ginsberg, B
    ANESTHESIA AND ANALGESIA, 1999, 89 (03): : 732 - 738
  • [40] Oral transmucosal fentanyl citrate (fentanyl oralet) vs oral midazolam for premedication in children
    Csontos, ER
    Lu, JK
    Schafer, PG
    Gay, MA
    East, KA
    Streisand, JB
    ANESTHESIA AND ANALGESIA, 1997, 84 : S423 - S423
12345