Novel series of CB2 selective antagonists for the treatment of autoimmune disorders: Synthesis, functional evaluation and ligand-steered modeling

被引：0
|
作者：
Phatak, Sharangdhar S.
Petrov, Ravil R.
Astruc-Diaz, Fanny
Cavasotto, Claudio N.
Diaz, Philippe
机构：
[1] Univ Texas Hlth Sci Ctr Houston, Sch Hlth Informat Sci, Houston, TX USA
[2] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 240卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
111-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Design, synthesis, and biological evaluations of 5-aryl-pyrazole-3-carboxamide derivatives as selective CB2 receptor agonists for the treatment of colitis
    Jiang, Bei-Er
    He, Ying
    Chen, Jie
    Jiang, Xing-Wu
    Qiu, Zi-Liang
    Liang, Qiu-Wen
    Gao, Xin-Long
    Zhang, Han-Kun
    Tian, Hai-Gang
    Liu, Ming-Yao
    Lu, Wei-Qiang
    Yu, Li-Fang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 283
  • [32] Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists
    Lange, JHM
    Coolen, HKAC
    van Stuivenberg, HH
    Dijksman, JAR
    Herremans, AHJ
    Ronken, E
    Keizer, HG
    Tipker, K
    McCreary, AC
    Veerman, W
    Wals, HC
    Stork, B
    Verveer, PC
    den Hartog, AP
    de Jong, NMJ
    Adolfs, TJP
    Hoogendoorn, J
    Kruse, CG
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (03) : 627 - 643
  • [33] Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists
    Zarrinmayeh, H
    Nunes, AM
    Ornstein, PL
    Zimmerman, DM
    Arnold, MB
    Schober, DA
    Gackenheimer, SL
    Bruns, RF
    Hipskind, PA
    Britton, TC
    Cantrell, BE
    Gehlert, DR
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (15) : 2709 - 2719
  • [34] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL SERIES OF NONPEPTIDE AT(2)-SELECTIVE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    WU, MT
    IKELER, TJ
    ASHTON, WT
    CHANG, RSL
    LOTTI, VJ
    GREENLEE, WJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (10) : 2023 - 2028
  • [35] Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
    Gomez, Laurent
    Massari, Mark Eben
    Vickers, Troy
    Freestone, Graeme
    Vernier, William
    Ly, Kiev
    Xu, Rui
    McCarrick, Margaret
    Marrone, Tami
    Metz, Markus
    Yan, Yingzhou G.
    Yoder, Zachary W.
    Lemus, Robert
    Broadbent, Nicola J.
    Barido, Richard
    Warren, Noelle
    Schmelzer, Kara
    Neul, David
    Lee, Dong
    Andersen, Carsten B.
    Sebring, Kristen
    Aertgeerts, Kathleen
    Zhou, Xianbo
    Tabatabaei, Ali
    Peters, Marco
    Breitenbucher, J. Guy
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (05) : 2037 - 2051
  • [36] Synthesis and Biological Evaluation of a Novel Series of G Protein-Coupled Estrogen Receptor Antagonists for The Treatment of Gallstone Disease
    DeLeon, Chlelsea
    Wilhelm, McKenna
    Sweeney, Patrick
    Arnatt, Christopher
    FASEB JOURNAL, 2017, 31
  • [37] Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation
    Basu, Sujay
    Barawkar, Dinesh A.
    Thorat, Sachin
    Shejul, Yogesh D.
    Patel, Meena
    Naykodi, Minakshi
    Jain, Vaibhav
    Salve, Yogesh
    Prasad, Vandna
    Chaudhary, Sumit
    Ghosh, Indraneel
    Bhat, Ganesh
    Quraishi, Azfar
    Patil, Harish
    Ansari, Shariq
    Menon, Suraj
    Unadkat, Vishal
    Thakare, Rhishikesh
    Seervi, Madhav S.
    Meru, Ashwinkumar V.
    De, Siddhartha
    Bhamidipati, Ravi K.
    Rouduri, Sreekanth R.
    Palle, Venkata P.
    Chug, Anita
    Mookhtiar, Kasim A.
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (02) : 681 - 694
  • [38] Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists
    Han, Shuang
    Zhang, Fei-Fei
    Xie, Xin
    Chen, Jian-Zhong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 74 : 73 - 84
  • [39] Design, synthesis, and biological activity of a novel series of adenosine A2A antagonists for the treatment of Parkinson's disease
    Moorman, Allan R.
    MacLennan, Stephen
    Borea, Pier Andrea
    Varani, Katia
    Heiss, Aaron
    Scannell, Michael
    El-hardy, Ahmed
    PURINERGIC SIGNALLING, 2008, 4 : S39 - S39
  • [40] Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2A Receptor Antagonists for the Treatment of Insomnia
    Xiong, Yifeng
    Ullman, Brett
    Choi, Jin-Sun Karoline
    Cherrier, Martin
    Strah-Pleynet, Sonja
    Decaire, Marc
    Dosa, Peter I.
    Feichtinger, Konrad
    Teegarden, Bradley R.
    Frazer, John M.
    Yoon, Woo H.
    Shan, Yun
    Whelan, Kevin
    Hauser, Erin K.
    Grottick, Andrew J.
    Semple, Graeme
    Al-Shamma, Hussien
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (15) : 5696 - 5706
12345