Pressure-induced structural changes in wet vitamin B12

被引：21
|
作者：
Fabbiani, Francesca P. A. [1 ]
Buth, Gernot [2 ]
Dittrich, Birger [3 ]
Sowa, Heidrun [1 ]
机构：
[1] Univ Gottingen, Abt Kristallog, GZG, D-37077 Gottingen, Germany
[2] Karlsruhe Inst Technol, Inst Synchrotronstrahlung ISS, D-76344 Eggenstein Leopoldshafen, Germany
[3] Univ Gottingen, Inst Anorgan Chem, D-37077 Gottingen, Germany
来源：
CRYSTENGCOMM | 2010年 / 12卷 / 09期
关键词：
CRYSTAL-STRUCTURE; STRUCTURE VALIDATION; CORRIN RING; PROTEIN; CRYSTALLOGRAPHY; B-12; DENATURATION; REFINEMENT; DEPENDENCE; MODEL;
D O I：
10.1039/c003378b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effects of pressure on the structure of cyanocobalamin (vitamin B12) have been investigated by compressing a single crystal grown from water together with its mother liquor to 1.0 GPa. The structure of a crystal grown from water in situ in a capillary has also been re-determined at room temperature and pressure. A conformational rearrangement of selected amide side chains, reduced displacement parameters and remarkable solvent ordering have been observed at high pressure.
引用
收藏
页码：2541 / 2550
页数：10
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