Pressure-induced structural changes in wet vitamin B12

被引：21

作者：

Fabbiani, Francesca P. A. ^{[1
]}

Buth, Gernot ^{[2
]}

Dittrich, Birger ^{[3
]}

Sowa, Heidrun ^{[1
]}

机构：

[1] Univ Gottingen, Abt Kristallog, GZG, D-37077 Gottingen, Germany

[2] Karlsruhe Inst Technol, Inst Synchrotronstrahlung ISS, D-76344 Eggenstein Leopoldshafen, Germany

[3] Univ Gottingen, Inst Anorgan Chem, D-37077 Gottingen, Germany

来源：

CRYSTENGCOMM | 2010年 / 12卷 / 09期

关键词：

CRYSTAL-STRUCTURE; STRUCTURE VALIDATION; CORRIN RING; PROTEIN; CRYSTALLOGRAPHY; B-12; DENATURATION; REFINEMENT; DEPENDENCE; MODEL;

D O I：

10.1039/c003378b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effects of pressure on the structure of cyanocobalamin (vitamin B12) have been investigated by compressing a single crystal grown from water together with its mother liquor to 1.0 GPa. The structure of a crystal grown from water in situ in a capillary has also been re-determined at room temperature and pressure. A conformational rearrangement of selected amide side chains, reduced displacement parameters and remarkable solvent ordering have been observed at high pressure.

引用

页码：2541 / 2550

页数：10

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