Axonal flip-flops and oscillators

被引：32
|
作者：
Baker, MD [1 ]
机构：
[1] UCL, Dept Biol, London WC1E 6BT, England
来源：
TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 11期
关键词：
D O I：
10.1016/S0166-2236(00)01645-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such as multiple sclerosis. A build-up of extracellular K+ in the internode and persistent Na+ currents are now implicated in generating the different forms of activity arising in normal and demyelinated axons.
引用
收藏
页码：514 / 519
页数：6
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