Aggregation-Induced Emission Materials that Aid in Pharmaceutical Research

被引：25
|
作者：
Wang, Bingnan [1 ]
Liu, Shanshan [1 ]
Liu, Xiaolin [2 ,3 ]
Hu, Rong [1 ]
Qin, Anjun [1 ]
Tang, Ben Zhong [1 ,2 ,3 ,4 ]
机构：
[1] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Prov Key Lab Luminescence Mol Aggregate, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China
[2] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong Branch,Inst Adv Study,Kowloon, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Clear Water Bay, Hong Kong 999077, Peoples R China
[3] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
[4] Chinese Univ Hong Kong, Shenzhen Inst Mol Aggregate Sci & Engn, Sch Sci & Engn, 2001 Longxiang Blvd, Shenzhen 518172, Guangdong, Peoples R China
来源：
ADVANCED HEALTHCARE MATERIALS | 2021年 / 10卷 / 24期
基金：
中国国家自然科学基金;
关键词：
aggregation-induced emission; AIE bioactive agents; AIE carriers; AIE prodrugs; drug delivery; ACTIVE THERANOSTIC AGENT; PRODRUG; DESIGN; CANCER; FLUORESCENCE; DELIVERY; PHOTOSENSITIZERS; DISCRIMINATION; POLYMERIZATION; VISUALIZATION;
D O I：
10.1002/adhm.202101067
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The in situ visualization of drugs can improve the understanding of their pharmacokinetics and mechanisms. Aggregation-induced emission (AIE) materials, which can aid in the visualization of drugs, are gradually being employed in pharmaceutical research due to their excellent fluorescence properties, good biocompatibility, and extremely high sensitivity. Herein, the progress of AIE materials in pharmaceutical research, including AIE carriers for drug delivery, AIE multifunctional prodrugs, and AIE compounds as bioactive reagents for theranostics is briefly described. Moreover, the opportunities and challenges of AIE materials in pharmaceutical research are discussed in depth. It is believed that versatile AIE materials hold great promise for the promotion of pharmacological research and can facilitate significant advancements in clinical fields.
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页数：18
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