Selective Targeting of Different Bromodomains by Small Molecules

被引：6

作者：

Qi, Jun ^{[1
,2
]}

Shi, Yang ^{[3
,4
,5
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Dept Pediat, Div Newborn Med, Boston, MA 02115 USA

[4] Boston Childrens Hosp, Dept Pediat, Epigenet Program, Boston, MA 02115 USA

[5] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

来源：

CANCER CELL | 2020年 / 37卷 / 06期

关键词：

D O I：

10.1016/j.ccell.2020.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two papers, published in Science and Nature, report inhibitiors selectively targeting distinct bromodomains of BET proteins. These advanced chemical tools facilitate functional understanding of epigenetic regulators in normal and disease states and enable development of new medicine potentially with lower toxicity.

引用

页码：764 / 766

页数：3

共 50 条

[31] Targeting bromodomains: epigenetic readers of lysine acetylation
Panagis Filippakopoulos
Stefan Knapp
Nature Reviews Drug Discovery, 2014, 13 : 337 - 356
[32] Targeting RNA with small molecules.
Tor, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U171 - U171
[33] Targeting Twist expression with small molecules
Pei, Haixiang
Li, Yunqi
Liu, Mingyao
Chen, Yihua
MEDCHEMCOMM, 2017, 8 (02) : 268 - 275
[34] Small molecules targeting viral RNA
Hermann, Thomas
WILEY INTERDISCIPLINARY REVIEWS-RNA, 2016, 7 (06) : 726 - 743
[35] Targeting RNA with small molecules.
Tor, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U162 - U162
[36] Targeting components of epigenome by small molecules
You, Jueng Soo
Han, Jeong Hwan
ARCHIVES OF PHARMACAL RESEARCH, 2014, 37 (11) : 1367 - 1374
[37] Targeting RNA with small molecules.
Tor, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U373 - U373
[38] Small Molecules Targeting Viral RNA
Mathez, Gregory
Cagno, Valeria
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (17)
[39] Targeting RNA structures with small molecules
Jessica L. Childs-Disney
Xueyi Yang
Quentin M. R. Gibaut
Yuquan Tong
Robert T. Batey
Matthew D. Disney
Nature Reviews Drug Discovery, 2022, 21 : 736 - 762
[40] Targeting RNA with small molecules.
Tor, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U206 - U206

← 1 2 3 4 5 →