Selective Targeting of Different Bromodomains by Small Molecules

被引：6

作者：

Qi, Jun ^{[1
,2
]}

Shi, Yang ^{[3
,4
,5
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Dept Pediat, Div Newborn Med, Boston, MA 02115 USA

[4] Boston Childrens Hosp, Dept Pediat, Epigenet Program, Boston, MA 02115 USA

[5] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

来源：

CANCER CELL | 2020年 / 37卷 / 06期

关键词：

D O I：

10.1016/j.ccell.2020.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two papers, published in Science and Nature, report inhibitiors selectively targeting distinct bromodomains of BET proteins. These advanced chemical tools facilitate functional understanding of epigenetic regulators in normal and disease states and enable development of new medicine potentially with lower toxicity.

引用

页码：764 / 766

页数：3

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