Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro (Reprinted)

被引：0
|
作者：
Regan, JD [1 ]
Trosko, JE
Carrier, WL
机构：
[1] Oak Ridge Natl Lab, Div Biol, Oak Ridge, TN 37830 USA
[2] Michigan State Univ, Dept Nat Sci, E Lansing, MI 48823 USA
来源：
DNA REPAIR | 2004年 / 3卷 / 01期
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D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Within 12-24 hr after human cells were irradiated with ultraviolet light, approximately 50% of the ultraviolet-induced pyrimidine dimers were lost from the DNA. Pyrimidine dimers were found in the TCA-soluble fraction of ultraviolet-irradiated cells at 24 hr. Excess thymidine, caffeine, or hydroxyurea. had no effect on the loss of pyrimidine dimers from the DNA of ultraviolet-irradiated cells.
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页码：92 / 98
页数：7
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