The flow synthesis of heterocycles for natural product and medicinal chemistry applications

被引：139

作者：

Baumann, Marcus ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr Adv Chem Synth, Cambridge CB2 1EW, England

来源：

MOLECULAR DIVERSITY | 2011年 / 15卷 / 03期

关键词：

Flow synthesis; Micro-reactor; Meso-reactor; Solid-supported reagents; Heterocycles; Automated synthesis; MULTISTEP SYNTHESIS; THROUGH SYNTHESIS; ORGANIC-SYNTHESIS; REACTORS; BATCH; MICROREACTOR; FLUORINATION; SCAVENGERS; ALKYNES; STEP;

D O I：

10.1007/s11030-010-9282-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we discuss some of our results with a main focus on the synthesis of heterocyclic compounds which we use in various natural product and medicinal chemistry programmes.

引用

页码：613 / 630

页数：18

共 50 条

[31] LOCKING UP PEPTIDE BACKBONES INTO SMALL HETEROCYCLES: CONFORMATIONAL PREFERENCES AND APPLICATIONS IN MEDICINAL CHEMISTRY
Gentilucci, L.
De Marco, R.
Greco, A.
JOURNAL OF PEPTIDE SCIENCE, 2014, 20 : S163 - S163
[32] Integrating natural product synthesis and combinatorial chemistry
Ganesan, A
PURE AND APPLIED CHEMISTRY, 2001, 73 (07) : 1033 - 1039
[33] Natural Product Synthesis at the Interface of Chemistry and Biology
Hong, Jiyong
CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (33) : 10204 - 10212
[34] Computational chemistry strategies in natural product synthesis
Elkin, Masha
Newhouse, Timothy R.
CHEMICAL SOCIETY REVIEWS, 2018, 47 (21) : 7830 - 7844
[35] Why are heterocycles so special in medicinal chemistry?
Yu, Bin
Yang, Xiuyan
CHEMICAL BIOLOGY & DRUG DESIGN, 2022, 100 (06) : 763 - 764
[36] Development of flow reactions to enable synthesis and medicinal chemistry
Beeler, Aaron
Fleming, Gabriel
Telmesani, Reem
Courtney, Alexis
Corre, Yann
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
[37] Application of Flow Micro Synthesis Technology for Medicinal Chemistry
Takayama, Masami
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2015, 73 (05) : 504 - 511
[38] NEW APPLICATIONS OF DIPOLAR CYCLOADDITION CHEMISTRY TOWARD THE SYNTHESIS OF HETEROCYCLES
PADWA, A
CHEN, YY
KOEHLER, KF
TOMAS, M
BULLETIN DES SOCIETES CHIMIQUES BELGES, 1983, 92 (09): : 811 - 817
[39] ORGN 45-Catalytic C-H bond functionalization for medicinal chemistry and natural product synthesis
Ellman, Jonathan A.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[40] Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry
Frecentese, Francesco
Saccone, Irene
Caliendo, Giuseppe
Corvino, Angela
Fiorino, Ferdinando
Magli, Elisa
Perissutti, Elisa
Severino, Beatrice
Santagada, Vincenzo
MEDICINAL CHEMISTRY, 2016, 12 (08) : 720 - 732

← 1 2 3 4 5 →