Stereotactic Body Radiotherapy Using CyberKnife® for Localized Low- and Intermediate-risk Prostate Cancer: Initial Report on a Phase I/II Trial

被引：3

作者：

Nakamura, Ryosuke ^{[1
]}

Hirata, Takero ^{[1
]}

Suzuki, Osamu ^{[1
]}

Otani, Keisuke ^{[1
]}

Kai, Naoki ^{[1
]}

Hatano, Koji ^{[2
]}

Fujita, Kazutoshi ^{[2
]}

Uemura, Motohide ^{[2
]}

Imamura, Ryoichi ^{[2
]}

Tanaka, Kazunori ^{[1
]}

Yoshioka, Yasuo ^{[3
]}

Nonomura, Norio ^{[2
]}

Ogawa, Kazuhiko ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Urol, Osaka, Japan

[3] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Radiat Oncol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 04期

关键词：

SBRT; CyberKnife; prostate cancer; INTENSITY-MODULATED RADIOTHERAPY; FRACTIONATION; BRACHYTHERAPY;

D O I：

10.21873/anticanres.14162

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The present study aimed to evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for localized prostate cancer. Patients and Methods: We investigated 25 patients treated with SBRT of 35 Gy per five fractions from May 2014 to March 2015. Results: The median age of patients was 70 years, four (16%) patients were low risk and 21 (84%) were intermediate risk. Seven (28%) patients received neoadjuvant androgen-deprivation therapy. The median follow-up time was 53 months. Grade 2 acute and late genitourinary toxicities were observed in five (20%) and two (8%) patients and there were no Grade 2 gastrointestinal toxicities. There were no Grade 3 or higher acute or late toxicities at 2 years follow-up. The biochemical relapse-free survival rate at 2 years was 100%. Conclusion: SBRT of 35 Gy per five fractions is a promising treatment method in the short term for prostate cancer.

引用

页码：2053 / 2057

页数：5

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