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Oral immunization against enterotoxigenic colibacillosis in weaned piglets by non-pathogenic Escherichia coli strain with K88 (F4) colonizing factors
被引:2
|作者:
Alexa, P
[1
]
Hamrik, J
[1
]
Stouracova, K
[1
]
Salajka, E
[1
]
机构:
[1] Vet Res Inst, Hudcova 70, CS-62132 Brno, Czech Republic
关键词:
piglet;
diarrhoea after weaning;
mucosal immunity;
F4;
fimbriae;
K88;
D O I:
10.17221/5629-VETMED
中图分类号:
S85 [动物医学(兽医学)];
学科分类号:
0906 ;
摘要:
Experiments were focused on the prevention of diarrhoea in weaned piglets by means of enterotoxigenic strains of Escherichia coli ( ETEC) with colonizing factors K88 (F4). The process of immunization consisted of intramuscular administration of ETEC strain bacterin one day prior to weaning and oral administration of a live culture of non-pathogenic E. coli strain containing colonizing factors (O149:K88; STa-, LT-) in 3 hours after weaning. The shedding of the K88 positive E. coli strains was monitored for 3 weeks after weaning by the culture of rectal swabs. The efficacy of such immunization protocol was tested by challenge exposure to enterotoxigenic E. coli O149: K88, LT+ strain on the third or the tenth day after weaning. Following the oral administration of non-pathogenic E. coli strain containing colonizing factors K88 to piglets, the shedding of the administered strain continued for 9 days. No or very small protection against diarrhoea following the challenge exposure to enterotoxigenic E. coli was found in immunized piglets.
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页码:315 / 320
页数:6
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