Expanding the membrane-protein NMR toolkit

被引：2
|
作者：
Cheng, Ricky C. [1 ]
Maduke, Merritt [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
NATURE CHEMICAL BIOLOGY | 2020年 / 16卷 / 09期
关键词：
D O I：
10.1038/s41589-020-0597-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An NMR method to monitor conformational states of challenging large protein targets is described. The method, which can be used to evaluate distances between two labels and to measure conformational exchange rates, revealed an unanticipated outward-facing state in a glutamate transporter.
引用
收藏
页码：937 / 938
页数：3
相关论文
共 50 条
  • [1] Expanding the membrane-protein NMR toolkit
    Ricky C. Cheng
    Merritt Maduke
    Nature Chemical Biology, 2020, 16 : 937 - 938
  • [2] Expanding the toolkit for membrane protein modeling in Rosetta
    Leman, Julia Koehler
    Mueller, Benjamin K.
    Gray, Jeffrey J.
    BIOINFORMATICS, 2017, 33 (05) : 754 - 756
  • [3] DIPOLAR CORRELATION NMR-SPECTROSCOPY OF A MEMBRANE-PROTEIN
    GRIFFITHS, JM
    LAKSHMI, KV
    BENNETT, AE
    RAAP, J
    VANDERWIELEN, CM
    LUGTENBURG, J
    HERZFELD, J
    GRIFFIN, RG
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (22) : 10178 - 10181
  • [4] Nuclear magnetic resonance (NMR) applied to membrane-protein complexes
    Kaplan, Mohammed
    Pinto, Cecilia
    Houben, Klaartje
    Baldus, Marc
    QUARTERLY REVIEWS OF BIOPHYSICS, 2016, 49 : 1 - 26
  • [5] DETERMINATION OF MEMBRANE-PROTEIN STRUCTURE BY ROTATIONAL RESONANCE NMR - BACTERIORHODOPSIN
    CREUZET, F
    MCDERMOTT, A
    GEBHARD, R
    VANDERHOEF, K
    SPIJKERASSINK, MB
    HERZFELD, J
    LUGTENBURG, J
    LEVITT, MH
    GRIFFIN, RG
    SCIENCE, 1991, 251 (4995) : 783 - 786
  • [6] DEVELOPMENT OF TOOLS FOR ORIENTED SAMPLE NMR APPROACHES TO MEMBRANE-PROTEIN STRUCTURE
    SCHWONEK, JP
    LANDIS, GC
    SANDERS, CR
    BIOPHYSICAL JOURNAL, 1994, 66 (02) : A37 - A37
  • [7] SOLID-STATE NMR APPROACHES FOR STUDYING MEMBRANE-PROTEIN STRUCTURE
    SMITH, SO
    PEERSEN, OB
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1992, 21 : 25 - 47
  • [8] PREDICTING A MEMBRANE-PROTEIN
    BLAKE, C
    NATURE, 1980, 285 (5762) : 190 - 191
  • [9] Membrane-protein topology
    von Heijne, Gunnar
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (12) : 909 - 918
  • [10] Membrane-protein engineering
    Mingarro, I
    vonHeijne, G
    Whitley, P
    TRENDS IN BIOTECHNOLOGY, 1997, 15 (10) : 432 - 437
12345