A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen

被引：22

作者：

Tao, ZF ^{[1
]}

Sowin, TJ ^{[1
]}

Lin, NH ^{[1
]}

机构：

[1] Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 44期

关键词：

indenopyrazole; pyrazoloindenone; oxidation; molecular oxygen; Suzuki coupling; Mitsunobu reaction; antitumor activity;

D O I：

10.1016/j.tetlet.2005.08.147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, convenient, and general synthetic method for indeno[1,2-c]pyrazole-4-ones through oxidation of indeno-pyrazoles by treatment with a base and molecular oxygen is described, and a possible mechanism for the oxidation is proposed. The product indeno[1,2-c]pyrazole-4-ones were elaborated further by Suzuki coupling and Mitsunobu reaction. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7615 / 7618

页数：4

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