A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen

被引：22
|
作者：
Tao, ZF [1 ]
Sowin, TJ [1 ]
Lin, NH [1 ]
机构：
[1] Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 44期
关键词：
indenopyrazole; pyrazoloindenone; oxidation; molecular oxygen; Suzuki coupling; Mitsunobu reaction; antitumor activity;
D O I：
10.1016/j.tetlet.2005.08.147
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, convenient, and general synthetic method for indeno[1,2-c]pyrazole-4-ones through oxidation of indeno-pyrazoles by treatment with a base and molecular oxygen is described, and a possible mechanism for the oxidation is proposed. The product indeno[1,2-c]pyrazole-4-ones were elaborated further by Suzuki coupling and Mitsunobu reaction. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7615 / 7618
页数：4
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